摘要
The safety of nanoparticle-based drug delivery systems(DDSs)for cancer treatment is still a challenge,restricted by the intrinsic cytotoxicity of drug carriers and leakage of loaded drug.Here,we propose a novel nanocarrier’s cytotoxicity avoidance strategy by synthesizing an encapsulation core–shell structure of zeolitic imidazolate framework-8(ZIF-8)-based colloid particles(CPs)with an amorphous ZIF-8 skin.This encapsulation structure achieves an ultra-high loading rate(LR)of 90%(i.e.,9 mg doxorubicin(DOX)per 1 mg ZIF-8)for DOX and the protection of DOX from leaking.Notably,to deliver unit-dose drug,this ultra-high LR of 90%significantly reduces the usage of ZIF-8 to 1.2%(2 orders of magnitude)compared to that of DOX@ZIF-8 with a 10%LR,in which cytotoxicity of ZIF-8 could well below the safety limit and then be relatively ignored.Safety,drug delivery efficacy,scale-up ability,and universality of this encapsulation structure have been further verified.Our findings suggest the great potential of this ZIF-8-based encapsulation core–shell structure in the field of drug delivery.
基金
supported by the National Natural Science Foundation of China(No.22101029)
the Beijing Natural Science Foundation(No.2222006)
the Beijing Municipal Financial Project BJAST Scholar Programs B(No.BS202001)
the Beijing Municipal Financial Project BJAST Young Scholar Programs B(No.YS202202)
the Beijing Municipal Financial Project BJAST Budding Talent Program(No.23CE-BGS-01).
作者简介
Address correspondence to:Xiangwen Liu,liuxiangwen@bcpca.ac.cn;Address correspondence to:Lanqun Mao,lqmao@bnu.edu.cn。
