摘要
目的 分析对早期产后出血患者采取卡前列素氨丁三醇联合纤维蛋白原浓缩物治疗的临床疗效。方法 30例早期产后出血患者,随机分为常规组与研究组,每组15例。常规组患者实施卡前列素氨丁三醇治疗,研究组患者实施卡前列素氨丁三醇联合纤维蛋白原浓缩物治疗。比较两组患者治疗效果、不良反应发生情况、产后出血量以及治疗前后凝血功能[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)]。结果 研究组治疗总有效率86.67%高于常规组的46.67%(χ^(2)=5.400, P=0.020<0.05)。研究组不良反应发生率13.33%低于常规组的60.00%(χ^(2)=7.034, P=0.008<0.05)。研究组产后2 h出血量(588.91±28.70)ml低于常规组的(638.09±35.34)ml,产后24 h出血量(639.36±56.52)ml低于常规组的(869.45±67.72)ml(P<0.05)。治疗后,研究组患者APTT(25.91±3.01)s、PT(11.02±0.41)s均短于常规组的(29.03±4.31)、(12.51±0.45)s(P<0.05)。结论 将卡前列素氨丁三醇联合纤维蛋白原浓缩物应用于早期产后出血患者的治疗中,用药不良反应发生率低,产后出血量也均得到有效减少,其效果明显,值得应用推广。
Objective To analyze the clinical efficacy of carboprost tromethamine combined with fibrinogen concentrate in the treatment of early postpartum bleeding.Methods 30 patients with early postpartum bleeding were randomly divided into the study group and the conventional group,with 15 cases in each group.Patients in the conventional group were treated with carboprost tromethamine,and patients in the study group were treated with carboprost tromethamine combined with fibrinogen concentrate.Comparison was conducted on the treatment effect,occurrence of adverse reactions,amount of postpartum bleeding,coagulation function[activated partial thromboplastin time(APTT),prothrombin time(PT)]before and after treatment between the two groups.Results The total effective rate of 86.67%in the study group was higher than 46.67%in the conventional group(χ^(2)=5.400,P=0.020<0.05).The incidence of adverse reactions in the study group was 13.33%,which was lower than 60.00%in the conventional group(χ^(2)=7.034,P=0.008<0.05).The amount of bleeding in the study group was(588.91±28.70)ml at 2 h postpartum,which was lower than(638.09±35.34)ml in the conventional group;the amount of bleeding in the study group was(639.36±56.52)ml at 24 h postpartum,which was lower than(869.45±67.72)ml in the conventional group(P<0.05).After treatment,the study group had APTT of(25.91±3.01)s and PT of(11.02±0.41)s,which were shorter than(29.03±4.31)and(12.51±0.45)s in the conventional group(P<0.05).Conclusion Carboprost tromethamine combined with fibrinogen concentrate for the treatment of early postpartum bleeding has low incidence of adverse drug reactions and less amount of postpartum bleeding.Its effect is obvious,and it is worth popularizing.
作者
周雪芳
ZHOU Xue-fang(Suzhou Industrial Park Xingpu Hospital,Suzhou 215126,China)
出处
《中国实用医药》
2024年第6期113-115,共3页
China Practical Medicine
