摘要
近年来,中药-化学药在临床实践中的联合应用非常广泛,其药物相互作用不容忽视。为优化药物的合理使用、拓宽药物的应用范围,定量药理学模型逐步被引入到药物相互作用的研究中,该模型种类涵盖较广,其中用于预测中药-化学药相互作用(herb-drug interaction,HDI)的模型主要包括药动学/药效学模型、群体药动学模型及生理药动学模型。通过对上述模型在HDI领域的应用进行概述,提炼定量药理学模型在HDI研究中的主要思路与方法,为中药和化学药的合理联用提供参考。
In recent years,the combined application of traditional Chinese medicine-chemical drugs in clinical practice is very common,and the drug interaction cannot be ignored.In order to optimize rational use and broaden application scope of drugs,pharmacometrics models are gradually being introduced into drug-drug interaction study.There is a wide range of pharmacometrics models,mainly including the pharmacokinetic/pharmacodynamic models,population pharmacokinetics models and physiologically based pharmacokinetics models,usually used to predict herb-drug interaction(HDI).This article intends to summarize the application of these models in HDI and establish the research strategy of pharmacometrics models in HDI,with view to providing references for further clinical rational combination of herbs and drugs.
作者
张露丹
左旭锐
刘凡琪
刘小梅
孙艳君
高晟玮
李自强
吕春晓
黄宇虹
ZHANG Ludan;ZUO Xurui;LIU Fanqi;LIU Xiaomei;SUN Yanjun;GAO Shengwei;LI Ziqiang;LYU Chunxiao;HUANG Yuhong(The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300150,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《中草药》
CAS
CSCD
北大核心
2024年第6期1799-1805,共7页
Chinese Traditional and Herbal Drugs
基金
天津市教委科研计划项目(2022ZD051)。
关键词
定量药理学
生理药动学模型
群体药动学模型
药动学/药效学模型
中药-化学药相互作用
pharmacometrics
physiologically based pharmacokinetics model
population pharmacokinetics model
pharmacokinetic/pharmacodynamic model
herb-drug interaction
作者简介
张露丹(1994-),女,博士研究生,研究方向为心血管疾病中医药防治与中药临床药理。E-mail:1311812604@qq.com;通信作者:吕春晓,女,副研究员,从事临床药理及相关研究。E-mail:lvchunxiao1989@163.com;通信作者:黄宇虹,女,研究员,博士生导师,从事临床药理与创新中药临床评价研究。E-mail:hyh101@126.com。
