摘要
慢性心力衰竭是一种进行性的、使患者身体衰弱的疾病,病死率和再住院率居高不下。据报道,我国慢性心力衰竭患者基数庞大且持续增加,已成为严重的社会公共卫生问题。近年来,虽然现代医学在药物治疗方面不断改进,但是仍无法克服其致死率高、不良反应明显等不足。中医学认为慢性心力衰竭病位在心,心气亏虚,推动无力,从而导致血脉瘀滞。因此,益气活血法是治疗慢性心力衰竭的有效方法。益气活血药是以补虚扶弱、疏通血脉为主要功效,以治疗气虚血瘀证为主的一类中药。其代表药物有人参、黄芪、丹参、当归、川芎等,是治疗慢性心力衰竭心气虚证的常用药物。人参、黄芪益气强心,配合当归、川芎活血化瘀,在缓解心气不足、心血不运中显示出了良好疗效。诸多研究表明益气活血类中药具有多成分、多途径、多靶点的特点,在改善慢性心力衰竭患者症状,提高生活质量方面具有独特优势。近期研究发现其作用机制与血流动力学、神经内分泌系统、内皮损伤、免疫调节、炎症因子、氧化应激、心肌能量代谢、心室重构、自噬和凋亡等机制有关。文章旨在总结益气活血类中药改善心功能的作用机制,以期为慢性心力衰竭气虚血瘀证的治疗提供新思路。
Chronic Heart Failure(CHF)is a progressive and debilitating disease with high mortality and rehospitalization rate.It has been reported that the large and increasing number of CHF patients has become a serious social and public health problem.In recent years,although modern medicine has made continuous improvements in drug therapy,but they still cannot overcome the deficiencies such as high fatality rate and obvious toxic side effects.Chinese medicine believes that CHF disease is located in theC heart,deficiency of heart and Qi(气),weakness of pushing,blood stasis and dysfunction of the Five-Zang(五脏)organs are the main pathogenesis of CHF.Therefore,supplementing Qi for activating blood circulation is an effective method to treat CHF.Supplementing Qi for activating blood circulation medicine(drugs for supplementing Qi and activating blood circulation)is a kind of TCM medicine with the main efficacy of tonifying deficiency and strengthening the weak,dredging blood vessels,and mainly treating Qi deficiency and blood stasis syndrome.Its representative medicines such as Renshen(Radix Ginseng),Huangqi(Radix Astragali),Danshen(Radix et Rhizoma Salviae Miltiorrhizae),Danggui(Radix Angelicae Sinensis),Chuanxiong(Rhizoma Chuanxiong)are commonly used in the treatment of heart-Qi deficiency syndrome of CHF.Renshen and Huangqi benefit Qi and strengthen heart,and cooperate with Danggui and Chuanxiong to promote blood stasis and relieve deficiency of heart Qi,shortness of breath and exhaustion,and bad blood flow.Many studies have shown that TCM for supplementing Qi and promoting blood circulation has the characteristics of multiple components,multiple approaches and multiple targets,showing unique advantages in improving symptoms and quality of life in patients with heart failure.However,its mechanism of action has not been fully clarified,which is an important issue to be solved urgently.Recent studies have found that its mechanism of action is related to hemodynamics,neuroendocrine system,endothelial injury,immune regulation,inflammatory factors,oxidative stress,myocardial energy metabolism,ventricular remodeling,autophagy and apoptosis.Therefore,the purpose of this paper is to summarize the mechanism of improving heart function by Supplementing Qi for activating blood circulation herbs,in order to provide new ideas for the treatment of CHF syndrome of Qi deficiency and blood stasis.
出处
《中医临床研究》
2024年第5期52-57,共6页
Clinical Journal Of Chinese Medicine
基金
甘肃省自然科学基金项目(21JR7RA581)
甘肃省中医药管理局项目(GZKZ-2020-09)
2021年度甘肃中医药大学科学研究与创新基金项目(2021KCYB-5)
甘肃省教育科技创新项目-青年博士基金(2021QB-080)
甘肃省教育科技创新项目-教育揭榜挂帅项目(2021jyjbgs-03)
中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者项目
甘肃省“双一流”科研重点项目(GSSYLXM-05)。
关键词
益气活血
慢性心力衰竭
机制
研究进展
Supplementing Qi for activating blood circulation
Chronic heart failure
Mechanism
Research progress
作者简介
张晓刚,在读研究生,研究方向为中西医结合防治心血管疾病;通讯作者:高永泽,在读研究生,研究方向为中西医结合防治心血管疾病。
