摘要
目的探讨肠道菌群紊乱与腹膜透析相关性腹膜炎的关系。方法收集2022年1—12月于该院进行规律腹膜透析的85例患者,根据是否发生腹膜透析相关性腹膜炎分为腹膜炎组(40例)和非腹膜炎组(45例)。比较两组肠道菌群分布差异,以及肠道菌群紊乱与腹膜炎发生的相关性。结果腹膜炎组患者肠道Eubacterium菌、罗氏菌、Absiella菌、毛螺菌丰度高于非腹膜炎组,阿克曼氏菌、肠球菌、萨特氏菌、普雷沃氏菌丰度低于非腹膜炎组,差异均有统计学意义(P<0.05)。相关性分析发现,肠道中有害菌群丰度与腹膜炎血液指标白细胞计数、中性粒细胞百分比以及C反应蛋白呈正相关(P<0.05),肠道中有益菌群丰度与白细胞计数、中性粒细胞百分比以及C反应蛋白呈负相关(P<0.05)。此外,粪便中短链脂肪酸(乙酸、丙酸和丁酸)水平与白细胞计数、中性粒细胞百分比以及C反应蛋白呈负相关(P<0.05),与肠道中肠球菌、阿克曼氏菌、萨特氏菌、普雷沃氏菌丰度呈正相关(P<0.05)。结论腹膜透析相关性腹膜炎的发生与患者肠道菌群紊乱密切相关,肠道菌群和粪便短链脂肪酸检测对腹膜透析相关性腹膜炎具有一定的辅助检测价值。
Objective To investigate the association of intestinal flora disturbance and peritoneal dialysis-related peritonitis.Methods A total of 85 patients with regular peritoneal dialysis in this hospital from January 2022 to December 2022 were collected and divided into the peritonitis group(40 cases)and non-peritonitis group(45 cases)according to whether peritoneal dialysis-related peritonitis occurring.The differences in the distribution of intestinal flora were compared between the two groups and the correlation between the intestinal flora disturbance and the occurrence of peritonitis was analyzed.Results The abundances of Eubacterium,Roseburia,Absiella and Lachnospiraceae in the peritonitis group were higher than those in the non-peritonitis group,while the abundances of Akkermansia,Prevotellaceae,Enterococcus and Sarteria were lower than those in the non-peritonitis group,and the differences were statistically significant(P<0.05).The correlation analysis demonstrated that the abundances of harmful bacteria in the intestinal tract was positively correlated with the blood indicators of peritonitis such as white blood cell count,neutrophil percentage and C-reactive protein(P<0.05),while the abundances of beneficial bacteria in the intestinal tract were negatively correlated white blood cell count,neutrophil percentage and C-reactive protein.Additionally,the fecal short-chain fatty acids(acetic acid,propionic acid,and butyric acid)levels were negatively correlated with white blood cell count,neutrophil percentage and C-reactive protein(P<0.05)and positively correlated with the abundances of enterococcus,Ackermannia,Sarteria and Prevotellaceae(P<0.05).Conclusion The occurrence of peritoneal dialysis-related peritonitis is closely related with intestinal flora disturbance of the patients,and detecting the intestinal flora and fecal short-chain fatty acids has a certain assisted detection value for peritoneal dialysis-associated peritonitis.
作者
何阶德
黄朦
黄存军
刘红玉
梁航
HE Jiede;HUANG Meng;HUANG Cunjun;LIU Hongyu;LIANG Hang(Department of Nephrology,Affiliated Hospital of Xiangnan University,Chenzhou,Hunan 423000,China;Department of General Medicine,Affiliated Hospital of Xiangnan University,Chenzhou,Hunan 423000,China)
出处
《检验医学与临床》
CAS
2024年第7期923-928,共6页
Laboratory Medicine and Clinic
基金
湘南学院校级课题医院联合项目(2021XJ94)。
关键词
腹膜透析
腹膜炎
肠道菌群
炎症因子
短链脂肪酸
peritoneal dialysis
peritonitis
intestinal flora
inflammatory cytokines
short-chain fatty acids
作者简介
何阶德,男,主治医师,主要从事肾内科疾病诊疗研究;通信作者:梁航,E-mail:lianghangxy2010@163.com。
