摘要
脑白质高信号(WMH)普遍存在于老年人群中,与卒中、认知、步态不稳和神经精神症状相关。WMH负荷通常随着年龄的增长而增加,但随着研究的不断深入,发现WMH是动态可变的,在发展过程中可能会部分消退,且可能伴随脑萎缩减缓和认知功能改善,但其确切发生机制、影响因素及临床意义目前尚不明确,且缺少有效逆转WMH的方法。作者综述了WMH消退的相关研究,为临床医师积极干预WMH相关影响因素,促进其在早期阶段逆转,改善患者脑健康提供参考。
White matter hyperintensities(WMH)is prevalent in the elderly population and is associated with stroke,cognition,gait instability,and neuropsychiatric symptoms.WMH burden usually increases with the growth of age.However,in recent years,there are researches found that WMH is actually dynamic variable.During the development,part of the WMH may regress,accompanied by the slowdown of brain atrophy and cognitive improvement.While,its mechanism,influencing factors and clinical significance remains unclear,and the effective treatment to reverse WMH is not clear.The article reviewed the current studies on the regression of WMH,aiming to provide reference for clinicians to actively perform intervention in the WMH related factors,promote their reversal in the early stage and improve the brain health of patients.
作者
徐玉芸
方琪芬
龚向阳
Xu Yuyun;Fang Qifen;Gong Xiangyang(Department of Radiology,Zhejiang Provincial People′s Hospital(People′s Hospital of Hangzhou Medical College),Hangzhou 310014,China)
出处
《中国脑血管病杂志》
CAS
CSCD
北大核心
2024年第3期188-193,共6页
Chinese Journal of Cerebrovascular Diseases
基金
浙江省基础公益研究计划项目(LGF22H090021)。
关键词
大脑小血管疾病
白质
磁共振成像
综述
Cerebral small vessel diseases
White matter
Magnetic resonance imaging
Review
作者简介
通信作者:龚向阳,Email:Gong.xy@vip.163.com。
