摘要
目的:探究血常规衍生炎症指标及协同刺激分子B7家族在系统性红斑狼疮患者中的表达。方法:选取2019年6月—2022年10月当阳市人民医院收治的164例系统性红斑狼疮患者及在本院体检的健康志愿者41例。系统性红斑狼疮疾病活动度指数(SLEDAI)评分≥15分患者为A组(n=41),SLEDAI评分10~14分患者为B组(n=41),SLEDAI评分5~9分患者为C组(n=41),SLEDAI评分0~4分患者为D组(n=41),体检健康者为E组(n=41)。比较五组的血常规衍生炎症指标[中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、中性粒细胞和单核细胞之和/淋巴细胞比值(NMLR)及衍生的中性粒细胞/淋巴细胞比值(dNLR)]及协同刺激分子B7家族,采用Pearson相关性分析血常规衍生炎症指标与协同刺激分子B7家族的关系。结果:A组、B组、C组及D组的血常规衍生炎症指标均显著高于E组,A组、B组及C组均显著高于D组,A组及B组均显著高于C组,A组均显著高于B组,差异均有统计学意义(P<0.05);A组、B组、C组及D组的协同刺激分子B7家族均显著低于E组,A组、B组及C组均显著均低于D组,A组及B组均显著低于C组,A组均显著低于B组,差异均有统计学意义(P<0.05);Pearson相关性分析显示,系统性红斑狼疮患者NLR、PLR、NMLR、dNLR与协同刺激分子B7家族3(B7-H3)、协同刺激分子B7家族4(B7-H4)均呈负相关(P<0.05)。结论:血常规衍生炎症指标及协同刺激分子B7家族在系统性红斑狼疮患者中的表达显著异常,且上述指标之间有密切的关系。
Objective:To investigate the expression of blood routine derived inflammatory indexes and costimulation molecule B7 family in patients with systemic lupus erythematosus.Method:A total of 164 patients with systemic lupus erythematosus and 41 healthy volunteers who underwent physical examination in Dangyang People's Hospital from June 2019 to October 2022 were selected.Patients with systemic lupus erythematosus disease activity index(SLEDAI)score≥15 scores were group A(n=41),patients with SLEDAI score 10-14 scores were group B(n=41),patients with SLEDAI score 5-9 scores were group C(n=41),patients with SLEDAI score 0-4 scores were group D(n=41)and the healthy person in physical examination were in group E(n=41).Blood routine derived inflammatory indexes[neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),the sum of neutrophil and monocyte/lymphocyte ratio(NMLR)and derived neutrophil/lymphocyte ratio(dNLR)]and the costimulation molecule B7 family were compared among the five groups.Pearson correlation was used to analyze the relationship between blood routine derived inflammatory indexes and costimulation molecule b7 family.Result:The blood routine derived inflammatory indexes of group A,B,C and D were significantly higher than those of group E,those of group A,B and C were significantly higher than those of group D,those of group A and B were significantly higher than those of group C,and those of group A were significantly higher than those of group B,the differences were statistically significant(P<0.05).The costimulation molecule B7 family in group A,B,C and D were significantly lower than those in group E,those in group A,B and C were significantly lower than those in group D,those in group A and B were significantly lower than those in group C,and those in group A were significantly lower than those in group B,the differences were statistically significant(P<0.05).Pearson correlation analysis showed that NLR,PLR,NMLR,dNLR were negatively correlated with costimulation molecule B7 family 3(B7-H3)and costimulation molecule B7 family 4(B7-H4)in SLE patients(P<0.05).Conclusion:The expression of blood routine derived inflammatory indexes and costimulation molecule B7 family is significantly abnormal in patients with systemic lupus erythematosus,and there is a close relationship between the above indicators.
作者
喻晨
刘庆丰
YU Chen;LIU Qingfeng(Department of Laboratory,Dangyang People's Hospital,Dangyang 444100,China;不详)
出处
《中国医学创新》
CAS
2024年第8期143-146,共4页
Medical Innovation of China
关键词
血常规衍生炎症指标
协同刺激分子B7家族
系统性红斑狼疮
疾病活动度
Blood routine derived inflammatory indexes
Costimulation molecule B7 family
Systemic lupus erythematosus
Disease activity
作者简介
通信作者:喻晨。
