摘要
目的探讨术后血清基质金属蛋白酶-2(MMP-2)、鳞状细胞癌抗原1(SCCA1)表达水平对鼻腔鼻窦内翻性乳头状瘤(SNIP)患者术后复发的预测价值。方法回顾性分析手术治疗的SNIP患者65例,根据术后2年内复发情况,将其分为复发组(n=12)和未复发组(n=53)。Elisa法检测手术前后血清MMP-2、SCCA1表达水平。收录临床资料,包括性别、年龄、饮酒史、吸烟史、肿瘤部位、手术方式、术后有无应用5-氟尿嘧啶(5-Fluorouracil,5-FU)、Krouse分期及有无糖尿病、高血压;Logistic回归分析影响SNIP患者术后复发的危险因素;ROC曲线分析术后血清MMP-2、SCCA1表达水平对SNIP患者术后复发的预测价值。结果术后,2组血清MMP-2、SCCA1表达水平均较术前降低(P<0.05),但复发组血清MMP-2、SCCA1表达水平均高于未复发组(P<0.05)。Logistic回归分析显示,有吸烟史、术后未应用5-FU、Krouse分期为T3~T4期、术后血清MMP-2表达水平、SCCA1表达水平是影响SNIP患者术后复发的危险因素(P<0.05)。ROC曲线分析显示,术后血清MMP-2、SCCA1表达水平单独及二者联合预测SNIP患者术后复发的曲线下面积(AUC)分别为0.786、0.800、0.836,敏感度分别为83.33%、75.00%、91.67%,特异度分别为71.70%、79.25%、75.47%。结论术后血清MMP-2、SCCA1表达水平可作为预测SNIP患者术后复发的辅助指标,且二者联合预测的效果更佳。
Objective To investigate the predictive value of postoperative serum matrix metalloproteinase-2(MMP-2)and squamous cell carcinoma antigen 1(SCCA1)expression levels for postoperative recurrence of sinonasal inverted papilloma(SNIP).Methods A retrospective analysis was performed on 65 SNIP patients,and they were divided into recurrence group(n=12)and non-recurrence group(n=53)according to the recurrence situation within 2 years after surgery.The expression levels of MMP-2 and SCCA1 in serum before and after operation were detected by Elisa.Clinical data including sex,age,alcohol and smoking history,tumor location,surgical procedure,postoperative use of 5-Fluorouracil(5-FU),Krouse stage,diabetes and hypertension were collected;Logistic regression was used to analyze the risk factors of postoperative recurrence in in patients with SNIP;ROC curve was used to analyze the predictive value of postoperative serum MMP-2 and SCCA1 expression levels for postoperative recurrence in patients with SNIP.Results After surgery,the serum levels of MMP-2 and SCCA1 in both groups were decreased compared with those before surgery(P<0.05),while the serum expression levels of MMP-2 and SCCA1 in recurrence group were higher than those in non-recurrence group(P<0.05).Logistic regression analysis showed that smoking history,no application of 5-FU after surgery,Krouse stage T3~T4,postoperative serum MMP-2 and SCCA1 expression level were risk factors for postoperative recurrence in patients with SNIP(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of postoperative serum MMP-2 and SCCA1 alone and combination was 0.786,0.800 and 0.836,respectively,the sensitivity was 83.33%,75.00%and 91.67%,respectively,and the specificity was 71.70%,79.25%and 75.47%,respectively.Conclusion The expression levels of postoperative serum MMP-2 and SCCA1 can be used as auxiliary indicators to predict postoperative recurrence in patients with SNIP,and the combined prediction effect is better.
作者
赵慧娜
李玉杰
杨长君
于敏
韩伟
ZHAO Huina;LI Yujie;YANG Changjun(Zhengzhou Central Hospital,Zhengzhou,450003)
出处
《实用癌症杂志》
2024年第4期547-550,561,共5页
The Practical Journal of Cancer
基金
河南省高等学校重点科研项目计划(编号:22B320014)。
