摘要
神经胶质瘤是对中枢神经系统有高度侵袭性的恶性肿瘤,需要积极进行手术和放化疗.但高级别胶质瘤[世界卫生组织(WHO)中枢神经系统肿瘤分类Ⅲ~Ⅳ级]预后仍较差,因此,迫切需要新的治疗策略.溶瘤病毒(OV)治疗是一种能特异性感染并有效杀死肿瘤细胞并且激活机体抗肿瘤免疫的免疫疗法.溶瘤疱疹病毒(oHSV)因其独特的优势有望成为神经胶质瘤新的辅助治疗手段,现从目前对oHSV的认识、OV抗肿瘤的机制、oHSV靶向治疗神经胶质瘤的临床研究现状、oHSV协同抗肿瘤策略的研究进展、oHSV抗神经胶质瘤研究中存在的问题进行综述,从而为神经胶质瘤的治疗提供参考.
Glioma is a highly aggressive malignant tumor of the central nervous system that necessitates active treatment through surgery,radiotherapy,and chemotherapy.However,the prognosis of high-grade gliomas[World Health Organization(WHO)classification of central nervous system tumorsgrade II-IV] remains poor,thus new treatment strategies are urgently needed.Oncolytic virus(OV)therapy is a kind of immunotherapy that can specifically infect and effectively kill tumor cells while activating anti-tumor immunity.The oncolytic herpes simplex virus(oHSV)is expected to emerge as a new adjuvant treatment for glioma due to its unique advantages.This article reviews the current understanding of oHSV,the anti-tumor mechanism of OV,the current clinical research status of oHSV targeted therapy for glioma,the research progress of oHSV collaborative anti-tumor strategy,and the existing problems in oHSV anti-glioma research,aiming to provide valuable insights for the treatment of glioma.
作者
杨海军
王亚涛
郑茂华
Yang Haijun;Wang Yatao;Zheng Maohua(The First Clinical College of Medicine,Lanzhou University,Lanzhou 730000,Gansu,China;Department of Laizriou 150000,Garsu,Neurosurgery,the First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China)
出处
《中国中西医结合急救杂志》
CAS
CSCD
北大核心
2023年第6期760-764,共5页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
甘肃省自然科学基金(21JR7RA356)。
作者简介
通信作者:郑茂华,Email:2002maohua@163.com。
