摘要
目的:观察宫腔灌注人绒毛膜促性腺激素(HCG)对反复种植失败(RIF)患者子宫内膜血流、辅助性T细胞17(Th17)和妊娠结局的影响。方法:回顾性分析连云港市妇幼保健院2020年3月~2022年12月期间收治的RIF行冻融囊胚移植的患者148例。根据冻融囊胚移植前是否进行宫腔灌注HCG分为对照组(n=71)和研究组(n=77),对照组接受常规子宫内膜准备方案,研究组则在对照组的基础上接受宫腔灌注HCG治疗。对比两组子宫内膜螺旋动脉血流参数、Th17细胞因子和妊娠结局。结果:两组移植后搏动指数(PI)、阻力指数(RI)下降,且研究组低于对照组(P<0.05)。两组移植后白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)、Th17细胞比例下降,且研究组低于对照组(P<0.05)。研究组的囊胚种植率、活产率、临床妊娠率高于对照组,生化妊娠率低于对照组(P<0.05),两组早期流产率组间对比无统计学差异(P>0.05)。结论:宫腔灌注HCG可有效改善RIF患者子宫内膜血流、Th17细胞水平以及妊娠结局,具有较好的临床应用价值。
Objective:To observe the effects of intrauterine infusion of human chorionic gonadotropin(HCG)on endometrial blood flow,helper T cell 17(Th17)and pregnancy outcome in patients with recurrent implantation failure(RIF).Methods:A retrospective analysis was performed on 148 patients with RIF who underwent freeze-thawing blastocyst transplantation in the Lianyungang Maternal and Child Health Hospital from March 2020 to December 2022.According to whether intrauterine infusion of HCG was performed before freeze-thawing blastocyst transplantation,they were divided into control group(n=71)and study group(n=77).The control group received conventional endometrial preparation regimen,while the study group received intrauterine infusion of HCG therapy on the basis of the control group.Blood flow parameters of endometrial spiral artery,Th17 cytokine and pregnancy outcome were compared in the two groups.Results:After transplantation,the pulsatile index(PI)and resistance index(RI)of two groups decreased,and the study group was lower than the control group(P<0.05).The proportion of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interleukin-17(IL-17)and Th17 cells of two groups after transplantation decreased,and the study group was lower than the control group(P<0.05).The blastocyst implantation rate,live birth rate and clinical pregnancy rate of the study group were higher than those of the control group,and the biochemical pregnancy rate was lower than that of the control group(P<0.05).There was no statistical difference in the early abortion rate in the two groups(P>0.05).Conclusion:Intrauterine infusion of HCG can effectively improve endometrial blood flow,Th17 cell level and pregnancy outcome in patients with RIF,and which has good clinical application value.
作者
李慧
唐淮云
汤丽莎
关慧娟
张帅
宋佳
赵佳慧
LI Hui;TANG Huai-yun;TANG Li-sha;GUAN Hui-juan;ZHANG Shuai;SONG Jia;ZHAO Jia-hui(Department of Reproductive Medicine,Affiliated Hospital of Kangda College of Nanjing Medical University/Lianyungang Maternal and Child Health Hospital,Lianyungang,Jiangsu,222062,China)
出处
《现代生物医学进展》
CAS
2023年第24期4697-4700,共4页
Progress in Modern Biomedicine
基金
江苏省卫生健康委科研课题(H2018014)。
关键词
宫腔灌注
人绒毛膜促性腺激素
反复种植失败
内膜血流
辅助性T细胞17
妊娠结局
Intrauterine perfusion
Human chorionic gonadotropin
Recurrent implantation failure
Endometrial blood flow
Helper T cell 17
Pregnancy outcome
作者简介
李慧(1982-),女,硕士,副主任医师,研究方向:生殖医学,E-mail:18036626563@163.com;通讯作者:唐淮云(1978-),女,硕士,主任医师,研究方向:生殖医学,E-mail:thylyg@163.com。
