摘要
长链非编码RNA(lncRNA)是一种主要分布在多种真核生物细胞中的长度大于200个核苷酸的非编码RNA,其本身不能编码蛋白质。静脉畸形作为一类先天性脉管畸形,随着基因测序技术的发展,对其分子发病机制了解日渐深入。lncRNA的异常表达可能与静脉畸形的发生、发展有密切联系。lncRNA可选择性调控血管内皮细胞和血管平滑肌细胞的增殖、凋亡及迁移等,从而影响静脉畸形的发生、发展。lncRNA有望成为静脉畸形一类新的诊断标志物或新的治疗靶点。
Long non-coding RNA(lncRNA)is a kind of non-coding RNA with a length of more than 200 nucleotides mainly distributed in a variety of eukaryotic cells.It cannot encode proteins itself.With the development of gene sequencing technology,the molecular pathogenesis of venous malformation is getting deeper and deeper.Abnormal expression of lncRNA may be closely related to the occurrence and development of venous malformations.LncRNA can selectively regulate the proliferation,apoptosis and migration of endothelial cells and vascular smooth muscle cells,thus the occurrence and development of venous malformations is affected.Therefore,lncRNA is expected to be a novel diagnostic marker or a new therapeutic target for venous malformations.
作者
张昊冉
林俊杰
乔军波
Zhang Haoran;Lin Junjie;Qiao Junbo(Key Laboratory of Hemangioma and Vascular Malformation of Henan Province,Department of Hemangioma Surgery,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450003,China)
出处
《中华整形外科杂志》
CSCD
北大核心
2024年第2期240-242,共3页
Chinese Journal of Plastic Surgery
基金
中关村精准医学基金会专项项目(2021[018])。
关键词
静脉畸形
长链非编码RNA
基因调控
血管内皮
Venous malformation
Long non-coding RNA
Gene regulation
Vascular endothelium
作者简介
通信作者:乔军波,Email:13939029769@163.com。
