摘要
痛性糖尿病周围神经病变(PDPN)是DM慢性并发症,我国PDPN患者占比较高。目前最新指南列出PDPN治疗的一线镇痛药物,大型随机试验证实联合用药的有效性,但PDPN病理生理机制尚未完全明确,临床治疗仍不理想。本文综述PDPN发生机制的研究进展。
Painful diabetic peripheral neuropathy(PDPN)is a chronic complication of diabetes mellitus.The proportion of patients.with PDPN is relatively high in China.At present,the latest guidelines recommend a batch of first-line analgesic drugs for PDPN treatment.Many large-scale randomized trials have confirmed the effectiveness of combination therapy.However,the pathological and physiological mechanisms of PDPN are not fully understood.The clinical treatment effect is still not ideal.This article reviews the research progress on the mechanism of PDPN occurrence.
作者
张轩玮
柳兴凤
聂开瑜
ZHANG Xuanwei;LIU Xinfeng;NIE Kaiyu(Zunyi Medical University,Zunyi 563000,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2024年第2期149-154,共6页
Chinese Journal of Diabetes
基金
省部共建协同创新中心项目(教科技厅函【2020】39号)。
关键词
痛性糖尿病周围神经病变
机制
脊髓背角
Painful diabetic peripheral neuropathy
Mechanism
Dorsal horn of thespinal cord
作者简介
通信作者:聂开瑜,Email:1147900529@qq.com。
