摘要
目的:探讨不同剂量甘露醇治疗颅脑损伤患者的效果。方法:选取2019年3月—2021年12月云浮市新兴县人民医院收治的颅脑损伤患者60例为研究对象。按照抽签法分为观察组和对照组,各30例。两组均行开颅手术,在常规止血、抗感染等治疗的基础上,对照组采用125 mL 20%甘露醇治疗,观察组采用250 mL 20%甘露醇治疗。比较两组患者颅内压控制情况、脑水肿体积、颅内压、住院时间、预后情况、并发症。结果:观察组颅内压降低显效时间、达到颅内压最低值时间短于对照组,差异有统计学意义(P<0.05);治疗后,两组脑水肿体积和颅内压降低,且观察组低于对照组,差异有统计学意义(P<0.05);观察组入住ICU时间、总住院时间短于对照组,预后不良率低于对照组,差异有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:与125 mL 20%甘露醇相比,250 mL 20%甘露醇治疗颅脑损伤的效果更好,可快速降低颅内压,减轻脑水肿,改善预后,且治疗的安全性尚可。
Objective:To investigate the effect of different dose of mannitol on patients with craniocerebral injury.Methods:Sixty patients with craniocerebral injury treated in Yunfu Xinxing County People's Hospital from March 2019 to December 2021 were selected as the study objects.They were divided into observation group and control group with thirty cases in each group.Both groups underwent craniotomy.On the basis of routine hemostasis and anti-infection treatment,the control group was treated with 125 mL 20%mannitol,and the observation group was treated with 250 mL 20%mannitol.The control of intracranial pressure,volume of cerebral edema,intracranial pressure,length of hospital stay,prognosis and complications were compared between the two groups.Results:The time for the reduction of intracranial pressure and the time to reach the minimum value of intracranial pressure in the observation group were shorter than those in the control group,the difference was statistically significant(P<0.05);after treatment,the volume of cerebral edema and intracranial pressure in two groups decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the length of ICU stay and total length of stay in observation group were shorter than control group,and the rate of poor prognosis was lower than control group,the difference was statistically significant(P<0.05);there was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion:Compared with 125 mL 20%mannitol,250 mL 20%mannitol has better effect in the treatment of craniocerebral injury,can rapidly reduce intracranial pressure,alleviate brain edema,improve prognosis,and the treatment safety is reasonable.
作者
黄子波
Huang Zibo(Yunfu Xinxing County People's Hospital,Yunfu 527400,Guangdong Province,China)
出处
《中外医药研究》
2023年第32期12-14,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
甘露醇
颅脑损伤
预后
Mannitol
Craniocerebral injury
Prognosis
