摘要
目的探究高血压合并冠心病患者冠状动脉病变严重程度与肾功能的相关性。方法选取2020年2月至2022年7月收治的高血压合并冠心病患者126例作为研究对象,根据冠状动脉造影(CAG)检查结果,将患者分为根据轻度冠状动脉狭窄(n=25)、中度冠状动脉狭窄(n=56)和重度冠状动脉狭窄(n=45),对比3组患者肾小球滤过率(eGFR)。根据美国的肾脏病患者生存质量指导对对象分为3组,分别为肾功能正常组(n=30)和肾功能轻度减低组(n=59)、肾功能中重度减低组(n=37),对比3组患者冠状动脉狭窄程度积分。利用Spearman相关性分析eGFR与冠状动脉狭窄积分、冠状动脉病变范围积分的相关性。将冠状动脉病变数作为因变量,年龄、性别、血脂、eGFR等指标作为自变量,进行采用Logistic回归分析冠状动脉病变的影响因素。结果不同冠状动脉狭窄程度患者性别比较差异无统计学意义(P>0.05),3组患者eGFR、年龄、吸烟、BMI、空腹血糖、TC、TG、HDL-C、LDL-C、尿酸对比具有明显差异(P<0.05)。不同肾功能患者冠状动脉病变范围积分、冠状动脉狭窄程度积分比较差异有统计学意义(P<0.05)。eGFR与冠状动脉狭窄积分、冠状动脉病变范围积分呈负相关,(R=-0.656、-0.584,P<0.05)。进行采用Logistic回归分析冠状动脉病变的影响因素,结果表明,年龄、吸烟、eGFR、尿酸是冠状动脉病变的独立影响因素(P<0.05),年龄≥60岁、吸烟、尿酸是独立危险因素(OR>1,P<0.05),eGFR≥90 mL·min^(-1)·1.73 m^(-2)是独立保护因素(OR<1,P<0.05)。结论eGFR与冠状动脉病变严重程度呈负相关。
Objective To explore the correlation between the severity of coronary artery disease and renal function in hypertension patients complicated with coronary heart disease.Methods A total of 126 hypertension patients complicated with coronary heart disease admitted to our hospital from February 2020 to July 2022 were selected as the research objects.According to the results of coronary angiography(CAG),they were divided into mild coronary artery stenosis(n=25),moderate coronary artery stenosis(n=56)and severe coronary artery stenosis(n=45).The glomerulaRfiltration rate(eGFR)of the three groups was compared.According to the Kidney Disease Quality of Life Instrument(KDQOL),patients were divided into normal renal function group(n=30),mild renal dysfunction group(n=59),and moderate-to-severe renal dysfunction group(n=37).The scores of coronary artery stenosis were compared among the three groups.The correlation of eGFRwith the scores of coronary artery stenosis and the extent of coronary artery lesions was identified by Spearman correlation analysis.With the number of coronary artery lesions as the dependent variable,and age,sex,blood lipid,eGFRand other indicators as independent variables,logistic regression was performed to analyze the influencing factors for coronary artery lesions.Results There was no significant difference in the gendeRbetween patients with different degrees of coronary artery stenosis(P>0.05),but there were significant differences in the eGFR,age,smoking,body mass index(BMI),fasting blood glucose,total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and uric acid among the three groups(P<0.05).There were significant differences in the scores of the extent of coronary artery lesions and coronary artery stenosis degree in patients with different levels of renal function(P<0.05).The eGFRwas negatively correlated with the scores of coronary stenosis and extent of coronary artery lesions(R=-0.656 and-0.584,respectively,P<0.05).Logistic regression showed that age,smoking,eGFR,uric acid were independent influencing factors for coronary artery disease(P<0.05).The age oveR60 years old,smoking and uric acid were independent risk factors(OR>1,P<0.05),while eGFR≥90mL/min/1.73m^(2) was an independent protective factor (OR<1,P<0.05).Conclusion The eGFRis negatively correlated with the severity of coronary artery disease.
作者
王艳丽
张佳
宋晓丛
WANG Yanli;ZHANG Jia;SONG Xiaocong(Department of Oncology,Zhangjiakou First Hospital,Hebei,Zhangjiakou 075000,China)
出处
《河北医药》
CAS
2024年第4期551-554,共4页
Hebei Medical Journal
基金
张家口市重点研发计划项目(编号:2121078D)。
关键词
高血压
冠心病
冠状动脉病变严重程度
肾功能
hypertension
coronary heart disease
severity of coronary artery disease
renal function
作者简介
通信作者:张佳,E-mail:wangyanli725@163.com。
