摘要
近年来,多糖因其安全性高、免疫活性好受到广泛关注。多糖体内过程的研究是多糖药物开发亟待解决的关键科学问题。目前在多糖药代动力学和免疫调节领域研究取得了一定进展。然而,由于多糖既缺少生色基团,又无光吸收基团,且多糖本身分子结构复杂,致使多糖体内过程和免疫调节作用机制的研究进展缓慢。有效地结合多种技术手段可以突破多糖体内难示踪、免疫调节机制不明的瓶颈,促进多糖的开发与利用。本文系统归纳总结了近年来在多糖体内过程及其免疫调节作用机制研究中的关键技术,以期为多糖的体内过程及免疫调节机制的研究提供技术借鉴和研究思路。
In recent years,polysaccharides have received much attention because of their high safety and good immunological activity.The study of polysaccharide in vivo process is a key scientific problem that needs to be solved for polysaccharide drug development.Some progress has been made in the field of polysaccharide pharmacokinetics and immunomodulation.However,due to the lack of both chromogenic and light-absorbing groups and the complex molecular structure of polysaccharides,the in vivo processes and immunomodulatory mechanisms of polysaccharides have been slow to be investigated.The effective combination of multiple techniques can break the bottleneck of difficult tracing and unknown immunomodulatory mechanism of polysaccharides in vivo,and promote the development and utilization of polysaccharides.In this paper,we systematically summarize the key techniques in the study of polysaccharide in vivo processes and immunomodulatory mechanisms in order to provide technical references and research ideas for the study of polysaccharide in vivo processes and immunomodulatory mechanisms.
作者
朱赤云
肖平
方悦悦
赖梦亭
段金廒
ZHU Chi-yun;XIAO Ping;FANG Yue-yue;LAI Meng-ting;DUAN Jin-ao(Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Key Laboratory of Chinese Medicinal Resources Recycling Utilization,National Administration of Traditional Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China)
出处
《药学学报》
CAS
CSCD
北大核心
2024年第2期322-335,共14页
Acta Pharmaceutica Sinica
基金
江苏省中医药科技发展计划项目(MS2021004)
江苏省中药资源产业化过程协同创新中心重点项目(ZDXM-2022-06)
国家自然科学基金资助项目(81703642)
南京中医药大学自然科学基金青年项目(NZY81703642)
国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-D-202005)
山东省重点研发计划(2021SFGC1203)。
关键词
多糖
药代动力学
免疫调节
作用机制
新技术
polysaccharide
pharmacokinetics
immunomodulation
mechanism of action
new technology
作者简介
通讯作者:肖平,Tel:86-25-85811917,E-mail:xiaoping@njucm.edu.cn;通讯作者:段金廒,dja@njucm.edu.cn。
