摘要
目的探讨非高密度脂蛋白胆固醇(non-HDL-C)、甘油三酯高密度脂蛋白胆固醇比值(TG/HDL-C)、甘油三酯葡萄糖乘积指数(TyG)对成年女性代谢综合征(MS)的诊断价值。方法本研究为横断面研究。选取2019年1月至2021年12月在西南医科大学附属医院健康管理中心体检且符合条件的24410例成年女性为研究对象。回顾性收集患者基本信息、体格检查资料、实验室相关指标等数据;采用多因素logistic回归分析non-HDL-C、TG/HDL-C、TyG与成年女性MS的关系;绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC)评估各指标对成年女性MS的诊断价值。结果成年女性中,MS检出率为3.3%;在校正年龄、体重指数、腰围、臀围、收缩压、舒张压、血尿酸、高血压病史、糖尿病病史、脂肪肝等混杂因素后,non-HDL-C(OR=1.608)、TG/HDL-C(OR=1.311)、TyG(OR=13.288)均是成年女性MS的危险因素;non-HDL-C、TG/HDL-C、TyG及三者联合AUC分别为0.795(95%CI:0.742~0.776)、0.909(95%CI:0.902~0.917)、0.942(95%CI:0.937~0.948)、0.944(95%CI:0.937~0.950),三者中TyG对成年女性MS诊断价值最优,最佳截断值为8.237,灵敏度和特异度分别为93.5%和85.5%。结论non-HDL-C、TG/HDL-C、TyG及三者联合均对成年女性MS有较好的诊断价值。
ObjectiveTo investigate the diagnostic value of non-high-density lipoprotein cholesterol(non-HDL-C),ratio of triglyceride to high-density lipoprotein cholesterol(TG/HDL-C),and triglyceride glucose index(TyG)on metabolic syndrome(MS)in adult women.MethodsThis was a cross-sectional study.A total of 24410 adult women who received health examination in health management center of the Affiliated Hospital of Southwest Medical University were selected from January 2019 to December 2021 as subjects.The subjects′basic information,physical examination results,and laboratory examination data were collected retrospectively.The relationship between non-HDL-C,TG/HDL-C,TyG,and MS in adult women were examined using multivariate logistic regression analysis.The receiver operating characteristic(ROC)curves were constructed and the area under the curve(AUC)were calculated to evaluate the diagnostic value of each indicator for MS in adult women.ResultsAmong 24410 adult females,800(3.3%)were found to have MS.After adjusting for age,body mass index,waist circumference,hip circumference,systolic blood pressure,diastolic blood pressure,blood uric acid,history of hypertension,history of diabetes,fatty liver,non HDL-C(OR=1.608),TG/HDL-C(OR=1.311),TyG(OR=13.288)were all risk factors for MS in adult women.non-HDL-C,TG/HDL-C,and TyG,as well as their combined AUC of ROC,were 0.795(95%CI:0.742-0.776),0.909(95%CI:0.902-0.917),0.942(95%CI:0.937-0.948),and 0.944(95%CI:0.937-0.950),respectively.TyG had the highest diagnostic value for MS in adult women among the three indicators,the optimal cutoff value for TyG was 8.237,with a sensitivity of 93.5%and a specificity of 85.5%.Conclusionnon-HDL-C,TG/HDL-C,TyG,as well as their combination,all demonstrate good diagnostic value for MS in adult women.
作者
梁轶
严忠婷
李晓红
王芳
桑玉还
袁媛
鞠梅
Liang Yi;Yan Zhongting;Li Xiaohong;Wang Fang;Sang Yuhuan;Yuan Yuan;Ju Mei(Health Management Center,Affiliated Hospital of Southwest Medical University,Luzhou 646000,China;Nursing College,the Southwest Medical University,Luzhou 646000,China;Nursing Department,Affiliated Hospital of Southwest Medical University,Luzhou 646000,China)
出处
《中华健康管理学杂志》
CAS
CSCD
北大核心
2024年第1期35-41,共7页
Chinese Journal of Health Management
基金
泸州市科技科研基金(2021-SYF-36)
自贡市哲学社会科学重点研究基地健康人文研究中心项目(JKRWY22-28)。
作者简介
通信作者:鞠梅,Email:593576753@qq.com。
