摘要
对昼夜节律调控排便相关胃肠生理功能的机制进行了综述。通过对国内外相关文献进行分析总结,分别从结肠运动、脑肠肽的分泌、肠道菌群及其代谢产物稳态和肠道屏障4个方面总结归纳了昼夜节律对排便相关胃肠生理功能的调控机制,并结合临床研究探讨了昼夜节律紊乱诱发功能性便秘(FC)的可能机制。昼夜节律紊乱导致胃肠功能失调可能诱发FC,治疗FC可以将优化患者生活作息、恢复昼夜节律作为导向,为未来用药提供了新思路。
This paper has reviewed the mechanism of circadian rhythm regulating of intestinal function.By analyzing and summarizing the relevant literature at home and abroad,this review summarizes the regulation of intestinal motility,brain-gut peptides secretion,gut microbiota homeostasis and intestinal barrier function by circadian rhythm and discusses the possible mechanism of functional constipation induced by circadian rhythm disruption based on clinical studies.Circadian rhythm regulates intestinal function,which affecting the invasion of constipation.Improving patients’daily life and reconstructing circadian rhythm may become a new strategy for the treatment of FC in the future.
作者
丁劭华
沈洪
DING Shaohua;SHEN Hong(The First School of Clinical Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China;Affiliated Hospital,Nanjing University of Chinese Medicine,Nanjing 210029,China)
出处
《陕西理工大学学报（自然科学版）》
2024年第1期80-86,94,共8页
Journal of Shaanxi University of Technology:Natural Science Edition
基金
国家中医药管理局全国名老中医药专家传承工作项目(No.国中医药人教函〔2021〕270号)
江苏省医学创新中心项目(No.苏卫科教〔2022〕15号)。
关键词
昼夜节律
便秘
胃肠
生理功能
研究进展
circadian rhythm
constipation
gastrointestine
physiology function
research progress
作者简介
通信作者:沈洪(1959-),男,江苏宿迁人,主任医师,教授,博士研究生导师,主要研究方向为中医内科学(消化-脾胃病学)。
