摘要
目的 探讨血清中性粒细胞/淋巴细胞比值(NLR)、单核细胞趋化蛋白-1(MCP-1)、白细胞介素-17(IL-17)在脑胶质瘤患者中的表达,并分析脑胶质瘤患者术后复发的影响因素。方法 纳入脑胶质瘤患者100例,按2∶1比例选取同期健康体检者50例为对照组。按照病理分级将100例患者分为低级别组54例(Ⅰ级28例、Ⅱ级26例)和高级别组46例(Ⅲ级25例、Ⅳ级21例)。收集所有受试者的一般临床资料及实验室检查结果,并分组进行比较。采用二元logistic回归分析评估脑胶质瘤患者术后复发影响因素;采用受试者工作特征(ROC)曲线分析NLR、MCP-1、IL-17诊断脑胶质瘤与评估脑胶质瘤病情的预测价值。结果 对照组、低级别组、高级别组患者血清NLR、IL-17水平依次升高,血清MCP-1水平依次降低(P<0.05)。二元logistic回归分析结果显示,NLR、IL-17、非全切、肿瘤直径>6 cm、高级别病变、低分化、侵袭浸润为胶质瘤术后复发危险因素,MCP-1、术后放化疗、术前KPS评分>70分为胶质瘤术后复发保护因素(P<0.05)。ROC曲线分析结果显示,NLR、MCP-1、IL-17诊断脑胶质瘤的ROC曲线下面积(AUC)分别为0.819、0.908、0.986;NLR、MCP-1、IL-17与及三者联合评估脑胶质瘤病情的AUC分别为0.790、0.897、0.754、0.996,均具有较好准确性。结论 血清NLR、MCP-1及IL-17水平可作为诊断脑胶质瘤及评估其病情的有效指标。NLR、IL-17、非全切、肿瘤直径>6 cm、高级别病变、低分化、侵袭浸润为脑胶质瘤患者术后复发的危险因素,MCP-1、术后放化疗、术前KPS评分>70分为其保护因素。
Objective To investigate the expression of serum neutrophil/lymphocyte ratio(NLR),monocyte chemotactic protein-1(MCP-1),interleukin-17(IL-17) in patients with glioma,and to analyze the influencing factors of postoperative recurrence in patients with glioma.Methods A total of 100 patients with brain glioma were included,and 50 healthy subjects were selected as control group according to the ratio of 2∶1.According to the pathological grade,100 patients were divided into a low-grade group((54 cases,including 28 cases of grade Ⅰ and 26 cases of grade Ⅱ)) and a high-grade group(46 cases,including 25 cases of grade Ⅲ and 21 cases of grade Ⅳ).General clinical data and laboratory results of all subjects were collected and compared in groups.Binary logistic regression analysis was used to evaluate the factors affecting postoperative recurrence of glioma patients.The predictive value of NLR,MCP-1 and IL-17 in the diagnosis and evaluation of glioma disease was analyzed by using receiver operating characteristic(ROC) curve.Results The levels of serum NLR and IL-17 in control group,low grade group and high grade group were increased by,while the level of serum MCP-1 was decreased successively(P<0.05).Binary logistic regression analysis showed that NLR,IL-17,incomplete resection,tumor diameter >6 cm,high-grade lesions,low differentiation,invasion and invasion were risk factors for postoperative recurrence of glioma.MCP-1,postoperative chemoradiation and preoperative KPS score >70 points were protective factors for postoperative recurrence of glioma(P<0.05).The curve analysis results of ROC showed that the ROC area under the curve(AUC) for the diagnosis of glioma by NLR,MCP-1 and IL-17 were 0.819,0.908 and 0.986,respectively.The AUC of NLR,MCP-1,IL-17 and the combined evaluation of brain glioma were 0.790,0.897,0.754 and 0.996,respectively,with good accuracy.ConclusionSerum levels of NLR,MCP-1 and IL-17 can be used as effective indicators for diagnosis and evaluation of brain glioma.NLR,IL-17,incomplete resection,tumor diameter >6 cm,high-grade lesions,low differentiation,invasion and invasion were the risk factors for postoperative recurrence in glioma patients.MCP-1,postoperative chemoradiation and preoperative KPS score >70 points were the protective factors.
作者
朱紫结
王勇
戈伟
Zhu Zijie;Wang Yong;Ge Wei(Cancer Center,Taikang Tongji(Wuhan)Hospital,Wuhan 430050,China;不详)
出处
《临床内科杂志》
CAS
2023年第12期825-828,共4页
Journal of Clinical Internal Medicine
作者简介
通讯作者:戈伟,E⁃mail:gewei514@126.com。
