摘要
目的基于双向两样本孟德尔随机化(MR)方法分析胃食管反流病(GERD)与慢性阻塞性肺疾病(COPD)的因果关系。方法从全基因组关联研究(GWAS)中获取GERD与COPD的遗传变异信息,并以此作为工具变量。采用逆方差加权法(IVW)、加权中位数法和MR-Egger回归分析法进行MR分析,并通过敏感性分析验证结果的稳健性。结果遗传预测的GERD与COPD发生风险具有显著正相关性,而COPD与GERD发生风险无统计学关联。正向IVW结果显示比值比(OR)=1.3057,95%置信区间(95%CI)为1.1144~1.5298,P=0.0009;逆向IVW结果显示OR=0.9823,95%CI为0.9174~1.0519,P=0.6104。敏感性分析未发现任何潜在偏倚。结论MR分析显示GERD是COPD的一个风险因子,治疗GERD可能有助于预防或延缓COPD的进展。
Objective To analyze the causal relationship between gastroesophageal reflux disease(GERD)and chronic obstructive pulmonary disease(COPD)based on the bidirectional two-sample Mendelian randomization(MR).Methods Genetic variation information of GERD and COPD was obtained from Genome-Wide Association Studies(GWAS)and used as instrumental variables.Inverse variance-weighted(IVW),weighted median and MR-Egger methods were used for MR analysis,and sensitivity analysis was performed to validate the robustness of the results.Results A significant positive correlation was observed between genetically predicted GERD and the incidence risk of COPD,but there was no statistical association between COPD and the incidence risk of GERD.Positive IVW result showed that the odds ratio(OR)was 1.3057,the 95% confidence interval(95%CI)was 1.1144 to 1.5298,and the P value was 0.0009;the reverse IVW result showed that the OR was 0.9823,the 95%CI was 0.9174 to 1.0519,and the P value was 0.6104.Sensitivity analysis did not find any potential bias.Conclusion MR analysis shows that GERD is a risk factor for COPD,and treating GERD may help prevent or delay the progression of COPD.
作者
刘波
游俊杰
郑思琳
黄敏
LIU Bo;YOU Junjie;ZHENG Silin;HUANG Min(School of Nursing,Southwest Medical University,Luzhou,Sichuan,646000;Department of Respiratory and Critical Care Medicine,the Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan,646000;Nursing Department,the Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan,646000)
出处
《实用临床医药杂志》
CAS
2024年第1期113-117,共5页
Journal of Clinical Medicine in Practice
基金
四川省干部保健科研课题资金资助项目(川干研2021-1503)。
关键词
胃食管反流病
慢性阻塞性肺疾病
孟德尔随机化
因果关系
遗传变异
gastroesophageal reflux disease
chronic obstructive pulmonary disease
Mendelian randomization
causal relationship
genetic variation
作者简介
通信作者:黄敏,E-mail:hm20140313@163.com。
