摘要
目的 探讨高剂量维生素D结合糖尿病医学营养治疗对妊娠期糖尿病伴肥胖孕妇的应用价值。方法 选取2020年7月—2022年8月厦门大学附属第一医院收治的妊娠期糖尿病伴肥胖孕妇70例为研究对象,按随机数表法分为观察组与对照组,每组35例。对照组采用糖尿病医学营养治疗,观察组在对照组的基础上增加高剂量维生素D治疗。对比两组糖代谢水平[空腹血糖(fasting plasma glucose, FPG)、餐后2 h血糖(2-hour postprandial blood glucose, 2 hPG)水平]、脂代谢水平[低密度脂蛋白胆固醇(low density lipoprotein-cholesterol, LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol, HDL-C)水平]、妊娠结局、不良新生儿结局。结果 干预后,观察组FPG、2 hPG、LDL-C水平均低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05)。观察组剖宫产、早产发生率分别为8.57%、11.43%,低于对照组的31.43%、40.00%,差异有统计学意义(P<0.05)。观察组不良新生儿结局发生率为5.71%,低于对照组的22.86%,差异有统计学意义(P<0.05)。结论 高剂量维生素D结合糖尿病医学营养治疗应用于妊娠期糖尿病伴肥胖产妇中,可改善患者糖代谢及脂代谢水平,降低不良妊娠结局发生率,减少剖宫产发生,不良新生儿结局发生率较低。
Objective To investigate the application value of high dose vitamin D combined with diabetes medical nutrition in pregnant women with gestational diabetes mellitus and obesity.Methods A total of 70 pregnant women with gestational diabetes mellitus and obesity admitted to the First Affiliated Hospital of Xiamen University from July 2020 to August 2022 were selected as the study objects and were divided into the observation group and the control group according to random number table method,with 35 cases in each group.The control group was treated with diabetes medical nutrition,and the observation group was added the high dose vitamin D combined therapy based on the contol group.The levels of glucose metabolism[fasting plasma glucose(FPG),2-hour postprandial blood glucose(2 hPG)],lipid metabolism[low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cholesterol(HDL-C)],pregnancy outcomes and adverse neonatal outcomes were compared between the two groups.Results After intervention,the levels of FPG,2 hPG,LDL-C in observation group were lower than those in control group,the HDL-C level was higher than that in control group,and the difference was statistically significant(P<0.05).The incidence rate of cesarean section and premature delivery in observation group were 8.57%and 11.43%,which were lower than 31.43%and 40.00%in control group,and the difference was statistically significant(P<0.05).The incidence rate of adverse neonatal outcomes in the observation group was 5.71%,which was lower than 22.86%in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of high dose vitamin D combined with diabetes medical nutrition therapy in pregnant women with gestational diabetes mellitus and obesity can improve the level of glucose metabolism and lipid metabolism of patients,reduce the incidence of adverse pregnancy outcomes,reduce the incidence of cesarean section,and the incidence of adverse neonatal outcomes is low.
作者
杨春源
洪海洋
李碧艳
YANG Chunyuan;HONG Haiyang;LI Biyan(Department of Pharmaceutical Preparation,the First Affiliated Hospital of Xiamen University,Xiamen,Fujian Province,361000 China)
出处
《糖尿病新世界》
2023年第23期55-58,共4页
Diabetes New World Magazine
关键词
妊娠
肥胖
糖尿病
高剂量维生素D
医学营养
Pregnancy
Obesity
Diabetes mellitus
High dose of vitamin D
Medical nutrition
作者简介
杨春源(1983-),男,本科,主管药师,研究方向为药学。;通信作者:李碧艳(1986-),女,本科,副主任药师,研究方向为药学,E-mail:303263830@qq.com。
