摘要
通过回顾性分析107例天疱疮住院病例临床资料,研究其病情受控前的各项指标,发现病情的轻重是影响皮质类固醇(下称激素)初始量、激素减量前时间、减量前激素总量、最大控制量和激素总量等指标的重要因素;加用免疫抑制剂可减少激素用量;红斑型天疱疮和疱疹样天疱疮病情轻,容易控制。对其中的55例进行了随访,发现患者的死亡率与年龄、天疱疮类型和有无应用免疫抑制剂有关,缓解率与病情轻重、住院间最大控制量和天疱疮类型相关。
We reviewed107cases of in-patient pemphigus which were diagnosed and classified based on clinical manifesta-tions,pathologic findings,DIF and IIF.Several parameters associated with control of state of the illness were studied.Disease severity is an important factor in influencing initial steroid dose,duration of steroid reduction,total steroid dosage before re-duction,disease-controlled maximal dose and total steroid dosage during hospitalization.Immunodepressant was helpful for re-duction of steroid dosage.PE and PH were easily controlled,and each parameter was less than that of PV and PF.Fifty-five cases fit for follow-up analysis.We found mortality was associated with age of disease onset,type of pemphigus and adjuvant therapy.The remission rate was related to disease severity,disease-controlled maximal dose during hospitalization and type of pemphigus.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2002年第12期756-759,共4页
Journal of Clinical Dermatology
