摘要
目的:分析帕立骨化醇治疗尿毒症继发性甲状旁腺功能亢进(SHPT)的效果。方法:选取2021年12月—2022年12月如皋市第三人民医院收治的80例尿毒症SHPT患者作为研究对象,随机分为两组,各40例。对照组采用阿法骨化醇治疗,观察组采用帕立骨化醇治疗。比较两组临床生化指标、不良反应发生情况、临床相关症状、治疗满意度。结果:治疗前,两组全段甲状旁腺激素(iPTH)、血清钙、血清磷、碱性磷酸酶水平比较,差异无统计学意义(P>0.05);治疗后,两组iPTH、血清磷、碱性磷酸酶水平低于治疗前,且观察组低于对照组,两组血清钙水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。观察组甲状旁腺体积小于对照组,疼痛、瘙痒评分低于对照组,差异有统计学意义(P<0.05)。观察组治疗总满意度高于对照组,差异有统计学意义(P<0.001)。结论:帕立骨化醇治疗尿毒症SHPT的效果显著,可改善患者临床生化指标与临床症状,提高治疗满意度,且不良反应较少。
Objective:To analyze the effect of paricalcitol in the treatment of secondary hyperparathyroidism(SHPT)induced by uremia.Methods:A total of 80 patients with uremia SHPT admitted to Rugao Third People's Hospital from December 2021 to De‑cember 2022 were selected as the study subjects and randomly divided into two groups,with 40 cases in each group.The control group was treated with alfacalcidol,and the observation group was treated with paricalcitol.The clinical biochemical indexes,the occurrence of adverse reactions,the clinically relevant symptoms,and the treatment satisfaction were compared between the two groups.Results:Before treatment,there was no significant difference in the levels of intact parathyroid hormone(iPTH),serum cal‑cium,serum phosphorus and alkaline phosphatase between the two groups(P>0.05);after treatment,the levels of iPTH,serum phosphorus and alkaline phosphatase in the two groups were lower than those before treatment,the levels in the observation group were lower than those in the control group,while the levels of serum calcium in the two groups were higher than those before treat‑ment,the levels in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The vol‑ume of parathyroid glands in the observation group was smaller than that in the control group,and the pain and itching scores in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The total satisfaction with treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.001).Conclusion:Paricalcitol has a significant effect in the treatment of uremia SHPT,which can improve the clinical biochemical indexes and clinical symptoms of patients,improve treatment satisfaction,and have fewer adverse reactions.
作者
孙彦林
Sun Yanlin(Internal Medicine Department,Rugao Third People's Hospital,Nantong 226531,Jiangsu Province,China)
出处
《中国社区医师》
2023年第34期25-27,共3页
Chinese Community Doctors
