摘要
目的观察扶正通淋散治疗脾肾两虚湿热内蕴型复发性尿路感染的临床疗效。方法将108例复发性尿路感染患者按照随机数字表方法分为3组,中药组36例予扶正通淋散治疗,西药组36例予临床常规西医治疗,联合组36例予扶正通淋散联合临床常规西医治疗。3组均治疗3个月,随访6个月。比较3组治疗前后尿常规[白细胞计数(WBC)、红细胞计数(RBC)]、尿细菌培养结果、血清炎症相关指标[肿瘤坏死因子α(TNF-α)、降钙素原(PCT)、白细胞介素6(IL-6)],治疗前及治疗结束后1个月健康调查简表(SF-36)评分,并统计临床疗效及复发率。结果联合组总有效率91.67%(33/36),中药组总有效率72.22%(26/36),西药组总有效率66.67%(24/36),联合组疗效优于中药组、西药组(P<0.05)。3组治疗后尿常规WBC、RBC均较本组治疗前降低(P<0.05),且联合组治疗后均低于中药组、西药组(P<0.05),中药组均低于西药组(P<0.05)。3组治疗后血清TNF-α、PCT、IL-6水平均较本组治疗前降低(P<0.05),且联合组治疗后均低于中药组、西药组(P<0.05),中药组均低于西药组(P<0.05)。3组治疗后SF-36量表各维度评分均较本组治疗前升高(P<0.05),且联合组均高于中药组、西药组(P<0.05)。联合组尿路感染复发率显著低于中药组、西药组(P<0.05)。结论扶正通淋散治疗脾肾两虚湿热内蕴型复发性尿路感染有较好疗效,可以显著改善患者炎症水平和生活质量,降低复发率。
Objective To observe the clinical efficacy of Fuzheng Tonglin Powder on recurrent urinary tract infection(rUTI)of spleen-kidney deficiency and damp-heat type.Methods One hundred and eight rUTI patients(spleen-kidney deficiency and damp-heat type)were randomly assigned to receive Fuzheng Tonglin Powder(traditional Chinese medicine[TCM]group,n=36)or routine Western medicine(Western medicine[WM]group,n=36)or Fuzheng Tonglin Powder+routine Western medicine(combined group,n=36).The three groups were treated for 3 months and followed up for 6 months,aiming to compareurine routine indexes(white blood cell count[WBC],red blood cell count[RBC]),urine bacterial culture indexes,serum inflammatory indexes(tumor necrosis factor alpha[TNF-α],procalcitonin[PCT],interleukin 6[IL-6]).The 36-item Short-Form Health Survey(SF-36)scores on day 0 and on month 1 of treatment were recorded,and the curative effect and recurrence rate were assessed.Results The overall effective rate in the combined group was better than that in the TCM group and WM group(91.67%[33/36]vs 72.22%[26/36],66.67%[24/36],[P<0.05],respectively).After treatment,WBC and RBC in the three groups were significantly decreased(P<0.05),which in the combined group weremore lower than TCM group and WM group(P<0.05),and TCM group wasmore lower than WM group(P<0.05).TNF-α,PCT,and IL-6 levels in the three groups decreased significantly(P<0.05),which in the combined group were the lowest,followed by TCM group and WM group(all P<0.05).The SF-36 scores in the three groups increased significantly(P<0.05),which in the combined group weremore higher than the other two groups(P<0.05).The recurrent rate of UTIin the combined group was significantly lower than the other two groups(P<0.05).Conclusion For rUTI patients(spleen-kidney deficiency and damp-heat type),Fuzheng Tonglin Powder has good curative effect,which can significantly improve inflammation level and quality of life,and reduce recurrence rate.
作者
刘兴国
聂晨
付明洁
曹繁华
杜冬琛
冯定华
LIU Xingguo;NIE Chen;FU Mingjie;CAO Fanhua;DU Dongchen;FENG Dinghua(Department of Nephrology,China Three Gorges University Affiliated Traditional Chinese Medicine Hospital(Yichang Hospital of Traditional Chinese Medicine),Yichang,Hubei 443000;Department of Traditional Chinese Medicine,Acupuncture and Rehabilitation,Yichang Maternal and Child Health Hospital,Yichang,Hubei 443000)
出处
《河北中医》
2024年第1期51-55,共5页
Hebei Journal of Traditional Chinese Medicine
基金
湖北省卫生健康委员会中医药科研项目(编号:ZY2019M065)。
关键词
复发性尿路感染
中西医结合疗法
Recurrent urinary tract infection
Integrated traditional Chinese and Western medicine therapy
作者简介
刘兴国(1970-),男,主任医师,学士。从事中西医结合肾病工作。研究方向:中西医结合肾病;通讯作者:付明洁(1983-),女,副主任医师,硕士。从事中西医结合肾脏疾病治疗工作。研究方向:中西医结合肾病。
