摘要
目的:观察痛风相关肾结石的中医证型分布规律,探讨痛风相关肾结石的病因病机;比较痛风肾结石组与痛风非肾结石组相关因素的差异,寻找痛风相关肾结石的潜在危险因素。方法:本研究采用横断面调查研究方法,以北京中医药大学东方医院风湿科门诊及住院部痛风患者为研究对象,共纳入116例痛风患者,按照有无肾结石将其分组。采集患者的一般资料、临床资料并进行中医辨证。使用SPSS 25.0统计软件进行相关数据分析。结果:(1)脾虚湿热证痛风患者肾结石发病率最高,其次是痰瘀痹阻证,湿浊内蕴证痛风患者肾结石发病率最低,但不同证型痛风患者肾结石发生率比较差异无统计学意义(P>0.05)。(2)两组患者痛风病程、三酰甘油(triglyceride,TG)和饮酒史差异存在统计学意义(P<0.05),相较于痛风非肾结石组,痛风肾结石组患者痛风病程更长,TG更高,有饮酒史的患者更多。(3)二元Logistic回归分析结果显示,痛风病程、TG是痛风患者并发肾结石的危险因素(P<0.05)。结论:(1)痛风相关肾结石与脾肾功能失调有关,基本病机可以概括为脾肾亏虚、湿热瘀结,临证还可以考虑从脾论治痛风相关肾结石。(2)痛风病程和TG是痛风相关肾结石的潜在危险因素。痛风患者病程越长、TG越高,发生肾结石的风险越大。
Objective:Observing the distribution of TCM syndrome types of gout related kidney stones,and toexplore the etiology and pathogenesis of gout related kidney stones;To compare the differences of related factors between gout kidney stone group and gout non kidney stone group,and to find the potential risk factors of related kidney stones.Methods:In this study,116 patients with gout in the outpatient and inpatient department of rheumatology department of Dongfang Hospital of Beijing University of traditional Chinese medicine were included according to the acceptance and excretion criteria,and they were divided into groups according to the presence or absence of kidney stones.The general and clinical data of patients were collected and TCM syndrome differentiation was carried out.SPSS 25.0 statistical software was used for relevant data analysis.Results:(1) The incidence rate of kidney stones in gout patients with spleen deficiency dampness heat syndrome was the highest,followed by phlegm stasis obstruction syndrome,and the incidence rate of kidney stones in gout patients with dampness turbidity internal accumulation syndrome was the lowest,but there was no significant difference in the incidence of kidney stones in gout patients with different syndrome types(P>0.05).(2) There were differences in gout course,triglyceride level and drinking history between the two groups(P<0.05).Compared with gout non kidney stone group,gout kidney stone group had longer gout course,higher triglyceride level and more patients with drinking history.(3) The results of binary logistic regression analysis showed that the course of gout and triglyceride were the risk factors of gout patients complicated with kidney stones(P<0.05).Conclusion:(1) The pathogenesis of gout related kidney stones is deficiency of spleen and kidney,dampness heat and blood stasis.We can also consider treating gout related kidney stones from the theory of spleen and dampness.(2) The course of gout and triglyceride may be the risk factors of renal calculi in patients with gout.The longer the course of gout and the higher the triglyceride level,the greater the risk of kidney stones.
作者
白雪娇
柏志义
王若伊
李媛
侯秀娟
BAI Xuejiao;BAI Zhiyi;WANG Ruoyi(Beijing University of Chinese Medicine,Bejing 100029)
出处
《中国中西医结合肾病杂志》
2023年第11期986-989,共4页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
北京市丰台区临床重点专科(风湿科)项目(No.040104001009)。
关键词
痛风
肾结石
证型
危险因素
Gout
Kidney stone
TCM syndrome type
Risk factor
作者简介
通讯作者:侯秀娟。
