摘要
肺炎支原体(Mycoplasma pneumoniae,MP)感染是一种异质性疾病。在临床中,诊断为支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)的患儿中,重症支原体肺炎(severe Mycoplasma pneumoniae pneumonia,SMPP)、难治性支原体肺炎(refractory Mycoplasma pneumoniae pneumonia,RMPP)和危重症MPP除带来治疗困难、预后差等严重影响儿童生命安全的情况外,还常遗留不同程度的后遗症。分析MPP重症化的影响因素,寻找早期识别MPP重症化的相关预警指标,对于进行早期干预,降低SMPP和RMPP的致残率和减少后遗症的发生,以及降低SMPP和RMPP的病亡率具有重要意义。在临床中,感染MPP的患儿对支原体耐药性、临床表现、实验室指标、影像学表现等,以及支气管肺泡灌洗术(bronchoalveolar lavage,BAL)的应用与MPP重症化发生相关,笔者对上述相关影响因素的研究进展予以综述。
Mycoplasma pneumoniae(MP)infection is a heterogeneous disease.Clinically,in children diagnosed with Mycoplasma pneumoniae pneumonia(MPP),severe Mycoplasma pneumoniae pneumonia(SMPP),refractory Mycoplasma pneumoniae pneumonia(RMPP)and critical MPP,in addition to causing serious impacts on children’s life safety such as treatment difficulties and poor prognosis,various degrees of sequelae often exist.To explore the influencing factors and to improve the early warning indicators of MPP severity,is of great significance for early intervention,reducing the morbidity and sequelae of SMPP and RMPP,and reducing the mortality rate of SMPP and RMPP.In clinical practice,mycoplasma drug resistance,clinical manifestations,laboratory indicators,imaging manifestations,and the application of bronchoalveolar lavage(BAL)in children infected with MPP are related to the occurrence of MPP severity.This paper reviews the research progress of the above related factors.
作者
刘力铭
李明
Liu Liming;Li Ming(Clinical College of Medicine,Dali University,Dali 671000,China;Department of Respiratory Medicine,Kunming Children’s Hospital,Kunming 650200,China)
出处
《结核与肺部疾病杂志》
2024年第1期81-87,共7页
Journal of Tuberculosis and Lung Disease
基金
云南省教育厅科学研究基金(2023Y0971)
云南省卫生科技计划(2018NS0173)。
关键词
支原体
肺炎
抗药性
体征和症状
临床实验室技术
支气管肺泡灌洗
Mycoplasma pneumoniae
Drug resistance
Signs and symptoms
Clinical laboratory techniques
Bronchoalveolar lavage
作者简介
通信作者:李明,Email:liming@etyy.cn。
