摘要
目的分析盐酸罂粟碱注射剂致药品不良反应(ADR)的一般规律与特点,为临床安全用药提供参考。方法以“罂粟碱”“不良反应”为主要检索词,检索中国知网(CNKI)、万方(WanFang)数据库自建库起至2023年1月涉及盐酸罂粟碱注射剂所致ADR的相关文献,统计并分析ADR的发生时间、原患疾病、给药途径、临床表现、不合理用药等信息。结果共检索到17篇文献,涉及23例患者,发生ADR 33例次。其中,男女性别比为6.67∶1,年龄45岁及以上占56.52%;ADR主要发生于用药10~30 min和1~2 d的患者占60.87%;给药途径为静脉滴注(39.13%)、肌肉注射(21.74%)、阴茎海绵体内注射(21.74%);原患疾病主要为椎动脉供血不足(17.39%)、骨折(13.04%)、心绞痛(13.04%)、阳痿(13.04%)、心肌缺血(13.04%)等。累及系统/器官以皮肤及其附件损害最多(7例次,21.21%),心率及心律紊乱5例次(15.15%),男性生殖系统损害5例次(15.15%),泌尿系统损害4例次(12.12%),胃肠系统损害4例次(12.12%);主要临床表现为尿潴留、阴茎异常勃起、多形性室速、过敏性休克、大疱性表皮松解萎缩坏死型药疹等。结论盐酸罂粟碱注射剂的ADR累及人体的多个组织和器官,临床表现呈多样性。临床应重视盐酸罂粟碱注射剂的ADR,加强用药监测,确保用药安全。
Objective To analyze the general patterns and characteristics of adverse drug reactions(ADRs)caused by Papaverine Hydrochloride Injection,and to provide a reference for rational drug use in the clinic.Methods Taking"Papaverine"and"Adverse Drug Reactions"as the keywords,relevant literature related to ADRs caused by Papaverine Hydrochloride Injection in the CNKI and WanFang databases was searched from their inception of the databases to January 2023.The occurrence time,primary disease,administration route,clinical manifestations,and irrational use of ADRs were statistically analyzed.Results A total of 17 studies were retrieved,involving 23 patients and 33 cases of ADRs.Among them,the gender ratio of male to female was 6.67∶1,and 56.52%of patients were aged 45 and above;60.87%of patients had ADRs occurring within 10-30 min and 1-2 d after medication;the administration routes were intravenous infusion(39.13%),intramuscular injection(21.74%),and intracavernous injection of the penis(21.74%);the main primary diseases were insufficient blood supply to the vertebral artery(17.39%),fractures(13.04%),angina(13.04%),erectile dysfunction(13.04%),and myocardial ischemia(13.04%);the most affected systems/organs were the skin and appendages disorders(7 cases,21.21%),heart rate disorders and arrhythmia(5 cases,15.15%),male reproductive disorders(5 cases,15.15%),urinary system damage(4 cases,12.12%),and gastrointestinal system damage(4 cases,12.12%);the main clinical manifestations were urinary retention,priapism,multiform tachycardia ventricular,anaphylactic shock,bullous epidermolysis,atrophy-necrosis drug eruption.Conclusion ADRs of Papaverine Hydrochloride Injection affect multiple tissues and organs in the human body,and the clinical manifestations are diverse.Clinical attention should be paid to the ADRs caused by Papaverine Hydrochloride Injection,and medication monitoring should be strengthened to ensure medication safety.
作者
张强
杨雪
张越
ZHANG Qiang;YANG Xue;ZHANG Yue(Baoji Branch of Shaanxi Provincial Drug and Vaccine Inspection Center,Baoji,Shaanxi,China 721013;Center for Drug Reevaluation of Henan,Zhengzhou,Henan,China 450008)
出处
《中国药业》
2024年第3期125-128,共4页
China Pharmaceuticals
关键词
罂粟碱
药品不良反应
文献分析
papaverine
adverse drug reactions
literature analysis
作者简介
第一作者:张强,男,大学本科,主管药师,研究方向为药品检查,(电话)0917-3853913(电子信箱)155239922@qq.com;通信作者:杨雪,女,硕士,工程师,研究方向为药品上市后的安全性评价,(电话)0371-65567116(电子信箱)854424057@qq.com。
