摘要
目的探讨杏芎氯化钠注射液联合琥珀酸美托洛尔缓释片治疗冠心病心绞痛的疗效及对血清CRP和IL-6水平影响。方法选取2019年1月—2020年12月中国人民武装警察部队河南总队医院收治的冠心病心绞痛患者62例,分为对照组(n=32)和观察组(n=30),对照组口服抗血小板、抗凝、降血脂、扩张血管等常规治疗。观察组在对照组基础上给予口服琥珀酸美托洛尔缓释片片(阿斯利康制药有限公司,规格47.5mg/片,国药准字J20050061),23.75mg/次,口服1次/d;杏芎氯化钠注射液(弘和制药有限公司,100 mL/瓶,国药准字H20058893)进行治疗,100 mL/次,静脉滴注,1次/d;两组持续治疗2周。对比两组治疗后临床疗效、心绞痛发作情况(硝酸甘油用量、心绞痛发作次数、发作持续时间)、心功能指标及血清CRP和IL-6水平变化。结果治疗后对照组12例显效,10例有效,6例无效,总有效率为68.75%;观察组16例显效,12例有效,2例无效,总有效率为93.33%;观察组疗效明显较高(P<0.05);经干预治疗后,两组患者的硝酸甘油服用剂量、心绞痛的发作次数以及持续的时间明显降低(P<0.05);并且观察组的疗效更加显著(P<0.05);两组患者经干预治疗,心功能的相关指标、血清炎性因子指标水平明显改善(P<0.05);且观察组改善较明显(P<0.05)。结论冠心病心绞痛患者在使用抗血小板聚集、抗凝血、降低血脂、扩张心血管等常规治疗基础上采用杏芎氯化钠注射液联合琥珀酸美托洛尔缓释片治疗具有较好的临床疗效,可降低血清CRP和IL-6水平,值得在临床上推广应用。
Objective To investigate the efficacy of Xingxiong sodium chloride injection combined with metoprolol succinate sustained-release tablets in the treatment of angina pectoris of coronary heart disease and the effects of serum CRP and IL-6 levels.Methods A total of 62 patients with angina pectoris of coronary heart disease admitted to our hospital from January 2019 to December 2020 were selected and divided into control group(n=32)and observation group(n=30).The control group was given routine treatment such as antiplatelet,anti-coagulation,reducing lipid,expanding blood vessal,etc.The observation group was given based on the control group metoprolol succinate sustained-release tablet(47.5mg/tablet,Approvol No.J20050061),23.75mg/time,1 time/d,Xingxiong sodium chloride(100 mL/bottle,Approvol No.H20058893),100 mL/time,iv.1 time/d,for 2 weeks.The clinical efficacy and angina attacks(dosage of nitroglycerin,frequency of angina attacks and duration of attacks)and cardiac function indexes and serum CRP and IL-6 levels were compared between the two groups after treatment.Results After treatment,12 cases in the control group were markedly effective,10 cases were effective,6 cases were ineffective,and the total effective rate was 68.75%.In the observation group,16 cases were markedly effective,12 cases were effective and 2 cases were ineffective.The total effective rate was 93.33%.The curative effect of the observation group was significantly higher(P<0.05).After treatment,the dosage of nitroglycerin,the frequency and duration of angina pectoris were significantly decreased(P<0.05).The decrease in the observation group,was more obvious(P<0.05).After treatment,the levels of cardiac function indexes and serum inflammatory factors were significantly improved(P<0.05).The improvement of observation group was more obvious(P<0.05).Conclusion Xingxiong sodium chloride injection combined with metoprolol succinate sustained-release tablets in the treatment of angina pectoris of coronary heart disease has good clinical efficacy,can reduce the levels of serum CRP and IL-6,and is worthy of clinical application.
作者
刘博
罗先润
相田园
LIU Bo;LUO Xian-Run;XIANG Yuan-yuan(Hospital of Henan Branch of Armed Police of PLA,Zhengzhou 450052,China;The First Medical Center of PLA General Hospital,Beijing 100853,China)
出处
《医药论坛杂志》
2023年第22期84-87,92,共5页
Journal of Medical Forum
基金
第63批博士后科学基金面上资助一等资助(2018M633675)。
关键词
杏芎氯化钠注射液
琥珀酸美托洛尔缓释片
冠心病心绞痛
临床疗效
血清CRP和IL-6水平
Xingxiong sodium chloride injection
Metoprolol succinate sustained-release tablets
Angina pectoris of coronary heart disease
Clinical effect
Serum CRP and IL-6 levels
作者简介
通信作者:相田园,E-mail:iangtianyuan54@163.com。
