摘要
卵巢癌因早期诊断困难、确诊时多为晚期以及高复发率,成为致死率最高的妇科肿瘤。卵巢癌不良预后的重要原因是对铂类抗肿瘤化疗药物的耐药。环状RNA(circRNA)因其特殊的结构在细胞中较mRNA更稳定,参与调控多种肿瘤的发生、发展及化疗耐药。circRNA可作为miRNA的竞争性内源性RNA(ceRNA)与蛋白结合,可通过调控巨噬细胞表型极化,和作为外泌体circRNA参与调控卵巢癌铂耐药的敏感性。circRNA有望成为新的铂耐药标志物及耐药治疗新靶点。为了进一步探讨circRNA与卵巢癌铂耐药的关系,本文对近年来有关circRNA与卵巢癌铂耐药相关研究的文献进行总结。
Ovarian cancer has become the most lethal gynecological tumor due to the difficulty in early diagnosis,the late stage when diagnosed and the high recurrence rate.Resistance to platinum-based anti-tumor chemotherapy drugs is an important reason for the poor prognosis of ovarian cancer.circular RNA(circRNA)is more stable than mRNA in cells due to its special structure,and it is involved in the regulation of the occurrence,development and chemotherapy resistance of a variety of tumors.circRNA can be used as a competing endogenous RNA(ceRNA)of miRNA to bind to proteins,and regulates the phenotypic polarization of macrophages,it can also be used as an exosomal circRNA to regulate the sensitivity of platinum resistance in ovarian cancer.circRNA is expected to be a new marker of platinum resistance and a new target for the treatment of platinum resistance.In order to further explore the relationship between circRNA and platinum resistance in ovarian cancer,this article summarizes the recent literature related to circRNA and platinum resistance in ovarian cancer.
作者
刘彬馨
范雅丹
吕春燕
梅子曼
邓青春
LIU Bin-xin;FAN Ya-dan;LYU Chun-yan;MEI Zi-man;DENG Qing-chun(Department of Gynecology,the Second Affiliated Hospital of Hainan Medical College,Haikou Hainan 570100,China)
出处
《局解手术学杂志》
2024年第2期179-182,共4页
Journal of Regional Anatomy and Operative Surgery
基金
2021年海南省自然科学基金高层次人才项目(821RC712)
2022年海南省重点研发计划项目(ZDYF2022SHFZ068)。
关键词
环状RNA
卵巢癌
铂耐药
机制
综述
circular RNA
ovarian cancer
platinum resistance
mechanism
review
作者简介
通信作者:邓青春,E-mail:qingchun0503@163.com。
