摘要
目的:有关于失眠的随机对照临床试验文献丰富,阅读文献发现目前关于中医治疗失眠的系统评价主要是从某个方剂或中成药、从不同证型、从中医外治法共三个方面进行系统评价,暂无从中医药治疗心肾不交型失眠进行系统评价的文献报道,文章对中医药治疗心肾不交型失眠进行荟萃分析,探索中医药治疗心肾不交型失眠的有效性和安全性,为临床用药提供循证医学依据。方法:在中国知网、万方医药期刊全文数据库、维普中文科技期刊等数据库中检索有关中医药治疗心肾不交型失眠的随机对照临床试验对纳入的文献进行质量评价与数据提取;利用RevMan 5.3软件进行数据分析。结果:共纳入随机对照临床试验文献11篇,共涉及患者820例。对数据分别采用临床总体有效率、匹兹堡睡眠质量指数、中医证候评分量表进行评价。Meta分析结果显示:9篇文献在中医药治疗心肾不交型失眠的临床总体有效率方面[RR=1.16,95%CI(1.08,1.24),P<0.0001]差异具有统计学意义。7篇文献在中医证候评分方面[MD=-4.91,95%CI(-6.62,-3.56),P<0.00001]差异具有统计学意义;8篇文献在降低匹兹堡睡眠指数方面[MD=-2.65,95%CI(-4.41,-0.90),P<0.01]差异具有统计学意义。结论:中医药在提高心肾不交型失眠的临床有效率、改善中医证候、降低匹兹堡睡眠质量指数方面具有很好的效果。但基于系统评价纳入的随机对照文献数量较少、质量不高,结论需要更大样本量、更严谨的随机对照临床试验支持。
Objective:There is a rich literature on randomized controlled clinical trials on insomnia,reading the literature found that the current systematic review of TCM treatment of insomnia is mainly from a certain prescription or TCM patent medicine,from different symptom types,from the external treatment of TCM medicine a total of three aspects of systematic review,there is no systematic review of TCM medicine treatment of cardiorenal insomnia for the literature reported,this article on the treatment of cardiorenal insomnia by TCM medicine Meta-analysis,explore the effectiveness and safety of TCM medicine in the treatment of cardiorenal insomnia,and provide evidence-based medical basis for clinical use.To conduct a Meta-analysis of TCM medicine in the treatment of insomnia with heart kidney imbalance,explore the effectiveness and safety of TCM medicine,and provide evidence-based medicine basis for clinical medication.Methods:The randomized controlled trials(RCTs)of TCM medicine in the treatment of insomnia of heart kidney imbalance type were searched in CNKI,Wanfang,VIP and other databases.The quality evaluation and data extraction of the included literatures were carried out.RevMan 5.3 software was used for data analysis.Results:A total of 11 RCTs literatures involving 820 patients were included.The data were evaluated by the clinical overall effective rate,Pittsburgh sleep quality index(PSQI)and TCM medicine syndrome rating scale.The results of Meta-analysis showed that there was a statistically significant difference in the total efficacy[RR=1.16,95%CI(1.08,1.24),P<0.0001]of 9 literatures.In terms of TCM syndrome score[MD=-4.91,95%CI(-6.62,-3.56),P<0.00001]showed statistically significant differences among the seven literatures.In terms of reducing PSQI[MD=-2.65,95%CI(-4.41,-0.90),P<0.01]showed statistically significant differences among the eight literatures.Conclusion:TCM medicine has a good effect in improving the clinical efficiency of heart and kidney imbalanced insomnia,improving the syndrome of TCM and reducing PSQI score.However,due to the small number and low quality of RCTs included in the systematic evaluation,the conclusion needs the support of larger sample size and more rigorous RCTs.
出处
《中医临床研究》
2023年第32期68-73,共6页
Clinical Journal Of Chinese Medicine
关键词
失眠
心肾不交
随机对照临床试验
META分析
Insomnia
Heart-kidney imbalanc
Randomized controlled clinical trials
Meta-analysis
作者简介
通讯作者:徐厚平。
