摘要
目的观察中医外治法中药药枕辅助治疗神经外科显微血管减压术后头痛患者的临床疗效及睡眠质量。方法选取2020年1月—2022年1月期间河北省人民医院收治的神经外科显微血管减压术后头痛患者90例作为研究对象,采用单纯随机抽样法分为对照组和观察组,每组各45例。对照组采用常规西药治疗,观察组在对照组基础上联合中医外治法中药药枕辅助治疗。治疗1个月后,观察比较两组患者临床疗效、不良反应发生情况,治疗前后视觉模拟评分法(Visual analogue scale,VAS)评分、匹兹堡睡眠质量评分(Pittsburgh sleep quality index,PSQI)、血清学指标[血清5-羟色胺(5-hydroxy tryptamine,5-HT)、β-内啡肽(β-endorphin,β-EP)、超氧化物歧化酶(Superoxide dismutase,SOD)]。结果治疗后观察组临床总有效率97.78%(44/45)高于对照组82.22%(37/45),差异有统计学意义(P<0.05)。治疗后两组患者VAS评分均较治疗前降低,差异有统计学意义(P<0.05);且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者PSQI评分均较治疗前降低,差异有统计学意义(P<0.05);且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清5-HT、β-EP、SOD水平均较治疗前升高,差异有统计学意义(P<0.05);且观察组高于对照组,差异有统计学意义(P<0.05)。治疗期间,观察组不良反应总发生率15.56%(7/45)与对照组11.11%(5/45)比较,差异无统计学意义(P>0.05)。结论在常规西药的基础上联合中医外治法中药药枕辅助治疗神经外科显微血管减压术后头痛有利于提高临床疗效,可减轻患者头痛、改善睡眠质量,可能与改善5-HT、β-EP、SOD等指标有关。
Objective To observe the clinical effect and sleep quality of headache patients after neurosurgical microvascular decompression assisted by a Chinese medicine pillow.Methods A total of 90 headache patients after neurosurgical microvascular decompression admitted to Hebei People′s Hospital from January 2020 to January 2022 were selected as the study objects,and they were divided into a control group and an observation group by simple random sampling method,with 45 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with a Chinese medicine pillow,an external treatment of traditional Chinese medicine,on the basis of the control group.The clinical efficacy,occurrence of adverse reactions,visual analogue scale(VAS)score,Pittsburgh sleep quality index(PSQI),and serological indicators[serum 5-hydroxy tryptamine(5-HT),β-endorphin(β-EP),and superoxide dismutase(SOD)]before and after treatment were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was 97.78%(44/45),higher than that of the control group 82.22%(37/45),and the difference was statistically significant(P<0.05).After treatment,VAS scores in both groups were lower(P<0.05),and the observation group was lower than the control group(P<0.05).After treatment,PSQI scores in the two groups were lower(P<0.05),and the observation group was lower than the control group(P<0.05).After treatment,the serum levels of 5-HT,β-EP,and SOD in the two groups were higher(P<0.05),and the observation group was higher than the control group(P<0.05).The total incidence of adverse reactions in the observation group was 15.56%(7/45).Compared with 11.11%(5/45)in the control group,there was no significant difference(P>0.05).Conclusion On the basis of conventional western medicine,a traditional Chinese medicine pillow,an external treatment of traditional Chinese medicine,is used to assist in the treatment of headaches after neurosurgical microvascular decompression,which is conducive to improving clinical efficacy,relieving headaches,and improving sleep quality,and it may be related to improving 5-HT,β-EP,SOD indicators.
作者
史皓威
石海亮
郭文昌
李洋
都毅辉
张阔
SHI Hao-wei;SHI Hai-liang;GUO Wen-chang;LI Yang;DU Yi-hui;ZHANG Kuo(Neurosurgery Department,Hebei Provincial People′s Hospital,Shijiazhuang Hebei 050000)
出处
《世界中西医结合杂志》
2023年第12期2483-2487,共5页
World Journal of Integrated Traditional and Western Medicine
基金
河北省中医药科技计划项目(2020206)。
关键词
神经外科显微血管减压术
头痛
中医外治法
睡眠质量
Neurosungical Microvascular Decompression
Headache
External Treatment of Tmditional Chinese Medicine
Sleep Quality
作者简介
通信作者:石海亮,Email:shihaowei1234@163.com。
