摘要
目的探讨缺血性脑卒中合并脑白质疏松患者认知功能与病变程度的相关性。方法选取2020年3月至2022年1月我院收治的98例缺血性脑卒中患者,根据是否合并脑白质疏松分为观察组和对照组,比较两组蒙特利尔量表(MoCA)和简易智能量表(MMSE)评分。比较脑室旁(PVH)和深部白质病变(DWMH)阳性组与阴性组性别、年龄、吸烟、饮酒、高血压、高血脂和冠心病等一般情况。分析认知功能与病变程度的相关性。结果观察组MoCA、MMSE认知功能评分低于对照组(P<0.05);观察组PVH阳性42例、阴性9例,DWMH阳性43例、阴性8例,两组性别、年龄、吸烟、饮酒、高血压、高血脂和冠心病一般情况比较差异无统计学意义(P>0.05),PVH阳性组及DWMH阳性组的MoCA和MMSE评分均低于阴性组(P<0.05);MoCA、MMSE认知功能与PVH和DWMH呈负相关(P<0.05)。结论缺血性脑卒中合并脑白质疏松患者认知功能与病变程度呈负相关,当缺血性脑卒中合并脑白质疏松患者病变程度越严重时,其认知功能障碍也越严重。
Objective To analyze the correlation between cognitive function and lesion degree in patients with ischemic stroke complicated with leukoaraiosis.MethodsNinety-eight patients with ischemic stroke admitted to our hospital from March 2020 to January 2022 were selected.According to whether patients were complicated with leukoaraiosis,the patients were divided into an experimental group and a control group.Montreal cognitive assessment(MoCA)and Minni-mental state examination(MMSE)scores were compared between the two groups:The lesions of the periventricular hyperrintensities(PVH)and the deep white matter hyperintensities(DWMH)were compared.The gender,age,smoking,drinking,hypertension,hyperlipidemia and coronary heart disease between PVH and DWMH lesion positive group and negative group were also compared.The correlation between cognitive function and lesion degree was analyzed.Results The scores of MoCA and MMSE in the experimental group were lower than those in the control group(P<0.05).There were 42 PVH positive cases,9 PVH negative cases,43 DWMH positive cases and 8 DWMH negative cases in the experimental group.There was no statistical significance in general conditions such as gender,age,smoking,drinking,hypertension,hyperlipidemia and coronary heart disease between the two groups(P>0.05).MoCA and MMSE in the PVH and DWMH positive group were lower than those in the PVH and DWMH negative group(P<0.05).The cognitive function of MoCA and MMSE was negatively correlated with PVH and DWMH(P<0.05).Conclusions The cognitive function of patients with ischemic stroke complicated with leukoaraiosis is negatively correlated with the degree of lesion.The more severe the lesion degree of patients with ischemic stroke complicated with leukoaraiosis is,the more serious the cognitive dysfunction is.
作者
孟玉
聂贝贝
金歌
孟玉杰
MENG Yu;NIE Bei-bei;JIN Ge;MENG Yu-jie(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《实用医院临床杂志》
2024年第1期133-136,共4页
Practical Journal of Clinical Medicine
基金
河南省医学科技攻关项目(编号:SBGJ201901012)。
关键词
缺血性脑卒中
脑白质疏松
认知功能
病变程度
相关性分析
Ischemic stroke
Leukoaraiosis
Cognitive function
Degree of lesion
Analysis of correlation
