摘要
构建相应的糖尿病动物模型对于深入了解糖尿病的发生机制、进行诊断以及开发新的治疗药物具有非常重要的意义。探索治疗肢体缺血的方法和了解其临床病理生理发展过程的重要途径是通过使用下肢缺血动物模型来实现的。近些年来,伴随着各种技术的快速进步,对于下肢动脉缺血模型和糖尿病模型的建立已经取得了越来越成熟的进展。这些模型的建立对于研究和理解下肢动脉缺血的机制以及糖尿病的影响具有重要的意义。而如何将这2种模型成功且稳定地制备对糖尿病下肢血管病变的发生机制、病理生理、治疗具有重要意义。本文将对糖尿病大鼠下肢缺血模型的建立方法展开综述,包括糖尿病大鼠模型及糖尿病下肢缺血模型的建立机制、方法以及评估相关指标。
Establishing appropriate animal models of diabetes is of great importance for gaining in-depth understanding of the pathogenesis of diabetes,conducting diagnosis,and developing novel therapeutic interventions.Exploring methods for treating limb ischemia and comprehending its clinical pathophysiological progression is a significant approach achieved through the use of animal models of lower limb ischemia.In recent years,with the rapid advancements of various techniques,the establishment of lower limb arterial ischemia models and diabetes models has made considerable progress.The establishment of these models carries vital implications for researching and comprehending the mechanisms underlying lower limb arterial ischemia and the impact of diabetes.Successfully and reliably preparing these two models is crucial for elucidating the pathogenesis,pathophysiology,and treatment of lower limb vascular lesions associated with diabetes.This paper provides an overview of the research on the establishment methods of a diabetic rat model of lower limb ischemia,covering the principles,methods,and relevant parameters of establishing a diabetic rat model and a lower limb ischemia model in diabetes.
作者
李虎
狄涛
再英·叶尔宝
田野
Li Hu;Di Tao;Zaiying·Yeerbao;Tian Ye(Department of Vascular and Thyroid Surgery,the First Affliated Hospital of Xinjiang Medical University,Urumqi 830011,China)
出处
《国际外科学杂志》
2023年第11期783-787,共5页
International Journal of Surgery
基金
新疆维吾尔自治区自然科学基金(2020D01C239)
省部共建国家重点实验室中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2020-20)。
关键词
糖尿病
疾病模型
动物
缺血
方法
Diabetes mellitus
Disease models,animal
Ischemia
Methods
作者简介
通信作者:田野,Email:chinese1018@126.com。
