摘要
目的分析中老年原发性微血管心绞痛(PMVA)患者口腔血链球菌(Ss)含量及血管内皮功能的改变。方法病例对照研究,选择杭州市红十字会医院心内科2019年1月至2022年7月诊断为PMVA的中老年患者21例(PMVA组),年龄45~80(63.4±12.3)岁;选择同期体检健康的23例为对照组,年龄48~76岁(62.5±6.5)岁;检测入选者口腔龈下菌斑中Ss的含量,同时测定其血浆血管性假血友病因子(vWF)及同型半胱氨酸(Hcy)水平,并进行Pearson直线相关分析。结果对照组口腔龈下菌斑中未检测到Ss;PMVA组患者口腔龈下菌斑可检测到低含量Ss,占比为1.754×10^(-4),(6.218×10^(-5),4.450×10^(-4));PMVA组患者vWF水平(20.22±4.44)μg/L较对照组(12.00±6.60)μg/L升高(t=4.890P<0.01);PMVA组Hcy水平(15.28±6.40)μmol/L,与对照组(12.86±2.63)μmol/L比较差异无统计学意义(t=1.615,P>0.05)。PMVA组口腔Ss含量与血浆vWF水平无相关性(r=0.038,P>0.05)。结论PMVA患者口腔龈下菌斑中可检测到Ss,而在健康中老年人中未检测到;PMVA患者vWF水平高于健康者,提示中老年PMVA患者存在血管内皮功能受损;PMVA患者口腔龈下菌斑中Ss含量与血vWF水平无相关性。
Objective To analyze levels of oral Streptococcus sanguinis(Ss)in middle-aged and elderly patients with primary microvascular angina(PMVA)and changes in vascular endothelial function.Methods In this case-control study,21 middle-aged and elderly patients diagnosed with PMVA at the Department of Cardiology,Hangzhou Red Cross Hospital between January 2019 and July 2022(the PMVA group)were recruited,with ages ranging from 45 to 80(63.4±12.3)years,while 23 healthy individuals receiving health checkups during the same period served as the control group,with ages ranging from 48-76(62.5±6.5)years.The 21 middle-aged and elderly PMVA patients underwent tests for the measurement of subgingival plaque Ss levels of the oral cavity and levels of plasma vascular von Willebrand factor(VWF)and homocysteine(Hcy).Pearson linear regression analysis was conducted.Results Ss was not found in subgingival plaque of the oral cavity in the control group,but low levels of Ss were detected in patients from the PMVA group(percentage:1.754×10^(-4);6.218×10^(-5),4.450×10^(-4)).The VWF level in the PMVA group was higher than in the control group[(20.22±4.44)μg/L us.(12.00±6.60)μg/L,t=4.890,P<0.01].There was no statistical difference in the Hcy level between the PMVA group and the control group[(15.28±6.40)μmol/L us.(12.86±2.63)μmol/L,t=1.615,P>0.05].There was no significant correlation between Ss levels and VWF levels in the PMVA group(r=0.038,P>0.05).Conclusions Ss can be detected in subgingival plaque of the oral cavity in PMVA patients,but not in healthy middle-aged and elderly people.The VWF level in PMVA patients is significantly higher than in healthy people,indicating that vascular endothelial function is impaired in middle-aged and elderly PMVA patients.However,there is no correlation between subgingival plaque Ss levels of the oral cavity and VWF levels in PMVA patients.
作者
黄琪
隋向前
裴德安
何武剑
王士生
胡新兰
Huang Qi;Sui Xiangqian;Pei Dean;He Wujian;Wang Shisheng;Hu Xinlan(Department of Cardiology,Hangzhou Red Cross Hospital,Hangzhou 310003,China;Department of Stomatology,Hangzhou Red Cross Hospital,Hangzhou 310003,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2023年第12期1468-1471,共4页
Chinese Journal of Geriatrics
基金
浙江省医药卫生科技计划项目(2020KY220,2019KY510)
浙江省中医药科技计划项目(2020ZA083)
作者简介
通信作者:胡新兰,Email:hbhxlyuer@163.com。
