摘要
肺癌是当今世界范围内发病率和死亡率最高的恶性肿瘤之一,尽管目前肺癌的治疗手段取得了重大进步,但其5年生存率仍然很低。铁死亡是一种以细胞内游离铁增加、脂质过氧化和活性氧累积为主要特征的细胞死亡方式。越来越多的证据表明,铁死亡在肺癌的发生发展中发挥了至关重要的作用,探索铁死亡在肺癌中的作用机制对于寻找新的肺癌诊断及治疗方法具有重要意义。本文就细胞铁死亡的调控机制及其在肺癌发生发展中的作用展开综述,以期为肺癌的诊断和治疗提供新的方向和思路。
Lung cancer is one of the malignant tumors with the highest incidence rate and mortality in the world today.Although significant progress has been made in the treatment of lung cancer,its 5-year survival rate is still very low.Ferroptosis is a cell death mode characterized by an increase in intracellular free iron,lipid peroxidation,and accumulation of reactive oxygen species.More and more evidence suggests that ferroptosis plays a crucial role in the occurrence and development of lung cancer,and exploring the mechanism of ferroptosis in lung cancer is of great significance for finding new diagnostic and treatment methods for lung cancer.This article reviews the regulatory mechanism of cell ferroptosis and its role in the occurrence and development of lung cancer,with the aim of providing new directions and ideas for the diagnosis and treatment of lung cancer.
作者
董宗富
王丽娜
张黎明
胡荣杭
Dong Zongfu;Wang Lina;Zhang Liming;Hu Ronghang(Clinical Medicine School,Jining Medical University,Jining 272000,China;Medical Research Center,Afiliated Hospital of Jining Medical University,Jining 272029,China;Department of Thoracic Surgery Affiliated Hospital of Jining Medical University,Jining 272029,China)
出处
《中国医师杂志》
CAS
2023年第11期1754-1757,共4页
Journal of Chinese Physician
基金
国家自然科学基金(81800182)。
关键词
铁死亡
肺肿瘤
脂质过氧化
Ferroptosis
Lung neoplasms
Lipid peroxidation
作者简介
通信作者:胡荣杭,Email:ronghanghu@163.com。
