摘要
目的:探讨复发性流产(RSA)患者子宫动脉血流参数、胰岛素抵抗与血清抗子宫内膜抗体(AEMAb)/抗心磷脂抗体IgG(ACA-IgG)的表达变化及其临床意义。方法:选取86例有复发性流产史的孕妇为RSA组,80例无异常妊娠史的孕妇为正常妊娠组。比较两组孕妇妊娠第6~10周空腹胰岛素(FINS)、空腹血糖(FBG)、ACA-IgG、AEMAb、胰岛素抵抗指数(HOMA-IR)、子宫动脉搏动指数(PI)及阻力指数(RI)、子宫动脉收缩期最大血流速度与舒张末期血流速度的比值(S/D);Spearmen、Pearson分析RSA患者PI、RI、S/D与胰岛素抵抗、血清指标的相关性。结果:两组孕妇FBG无统计学差异(P>0.05)。RSA组孕妇PI、RI、S/D大于正常妊娠组(P<0.05);ACA-IgG、AEMAb阳性率及血清HOMA-IR、FINS浓度高于正常妊娠组(P<0.05)。Spearmen相关性分析显示,PI、S/D、RI与ACA-IgG、AEMAb表达水平呈正相关(P<0.05)。Pearson相关性分析显示,PI、S/D、RI与HOMA-IR、FINS水平呈正相关(P<0.05)。结论:RSA患者S/D、PI、RI、ACA-IgG及AEMA阳性表达率、HOMA-IR、FINS均高于正常妊娠孕妇;RSA孕妇PI、RI、S/D与HOMA-IR、FINS、ACA-IgG、AEMAb均呈正相关。
Objective:To explore the expression and clinical significance of uterine artery flow parameters,insulin resistance and serum anti-endometrial antibody(AEMAb)/anti-cardiolipin Antibody IgG(ACA-IgG)in patients with recurrent abortion(RSA).Methods:86 pregnant women with a history of recurrent abortion were selected as RSA group,and 80 pregnant women with no history of abnormal pregnancy were included as normal pregnancy group.The fasting insulin(FINS),fasting blood glucose(FBG),ACA-IgG,AEMAb,insulin resistance index(HOMA-IR),uterine artery pulse index(PI),resistance index(RI)and the ratio of maximum systolic blood flow velocity to end-diastolic blood flow velocity(S/D)of the uterine artery of regnant women during 6~10 weeks were compared between the two groups.Spearmen and Pearson were used to analyze the correlation between PI,RI,S/D and insulin resistance and serum indexes in RSA patients.Results:There was no statistically significant difference in FBG between the two groups(P>0.05).The PI,RI,and S/D of pregnant women in the RSA group were higher than those in the normal pregnancy group(P<0.05),and the positive rates of ACA-IgG and AEMAb,as well as the serum HOMA-IR and FINS concentrations,were higher than those in the normal pregnancy group(P<0.05).Spearmen correlation analysis showed that PI,S/D,RI were positively correlated with the expression of ACA-IgG and AEMAb(P<0.05).Pearson correlation analysis showed that PI,S/D,RI were positively correlated with HOMA-IR,FINS(P<0.05).Conclusion:The S/D,PI,RI,positive expression of ACA-IgG and AEMA,HOMA-IR,and FINS of RSA patients are higher than those of normal pregnant women.At the same time.There is a certain correlation between PI,RI,S/D and HOMA-IR,FINS,ACA-IgG and AEMAb in RSA patients.
作者
蔡杰
王宾红
李艺
CAI Jie;WANG Bin-hong;LI Yi(Department of Gynecology,Tongzhou District Maternal and Child Health Hospital,Beijing 101100,China;Department of Reproductive Health,Tongzhou District Maternal and Child Health Hospital,Beijing 101100,China;Department of Traditional Chinese Medicine,Tongzhou District Maternal and Child Health Hospital,Beijing 101100,China)
出处
《川北医学院学报》
CAS
2023年第11期1547-1550,共4页
Journal of North Sichuan Medical College
基金
北京市通州区科技计划项目(KJ2019CX011)。
关键词
复发性流产
子宫动脉血流状态
胰岛素抵抗
抗心磷脂抗体IgG
抗子宫内膜抗体
Recurrent abortion
Uterine arterial blood flow status
Insulin resistance
Anti-cardiolipin Antibody IgG
Anti-endometrial antibody
作者简介
蔡杰(1984-),女,主治医师。E-mail:caijie202303@163.com。
