摘要
目的:探讨血清miR-499-5p、miR-423-5p及miR-210-3p水平对冠心病患者并发左心室肥厚的预测价值。方法:选取198例冠心病患者为研究对象,根据是否并发左心室肥厚分为并发组(n=82)和未并发组(n=116)。比较两组患者一般资料、血清miR-499-5p、miR-423-5p、miR-210-3p、血脂及细胞因子水平,Logistic回归分析影响冠心病患者并发左心室肥厚的因素,受试者工作特征曲线(ROC)分析血清miR-499-5p、miR-423-5p及miR-210-3p水平对冠心病患者并发左心室肥厚的预测价值。结果:两组患者高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平无统计学差异(P>0.05)。并发组患者年龄、血清miR-499-5p、miR-423-5p、miR-210-3p及总胆固醇(TC)水平、中性粒细胞/淋巴细胞(NLR)及血小板/淋巴细胞比值(PLR)高于未并发组(P<0.05)。Logistic回归分析结果显示,患者年龄大、血清miR-499-5p、miR-423-5p、miR-210-3p及TC水平较高、NLR及PLR值较高是导致响患者冠心病患者并发左心室肥厚的相关因素(P<0.05)。ROC曲线分析显示,年龄、miR-499-5p、miR-423-5p、miR-210-3p、TC、NLR及PLR对预测冠心病患者并发左心室肥厚均较高价值,且各指标联合预测的价值更高(P<0.05)。结论:患者年龄大、微小核酸(miR-499-5p、miR-423-5p、miR-210-3p)及TC水平较高、NLR及PLR值较高是导致冠心病患者并发左心室肥厚风险因素,微小核酸、TC、NLR及PLR联合检测对预测冠心病患者并发左心室肥厚有较高价值。
Objective:To investigate the predictive value of serum miR-499-5p,miR-423-5p and miR-210-3p levels in patients with coronary heart disease complicated with left ventricular hypertrophy.Methods:198 patients with coronary heart disease were selected and divided into concurrent group(n=82)and non-concurrent group(n=116)according to whether left ventricular hypertrophy was complicated.The general data of the two groups of patients were compared,serum miR-499-5p,miR-423-5p,miR-210-3p levels,blood lipid and serum cytokine levels.Logistic regression analysis was used to analyze the factors that affect left ventricular hypertrophy in patients with coronary heart disease.Receiver operating characteristic curve(ROC)was used to analyze the predictive value of serum miR-499-5p,miR-423-5p,and miR-210-3p levels in patients with coronary heart disease complicated with left ventricular hypertrophy.Results:There was no significant difference between the levels of high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)between the two groups(P>0.05).The age,serum levels of miR-499-5p,miR-423-5p and miR-210-3p,total cholesterol(TC),neutrophil/lymphocyte(NLR)and platelet/lymphocyte ratio(PLR)were higher than those in the non-concurrent group(P<0.05).The results of Logistic analysis showed that the age,miR-499-5p,miR-423-5p,miR-210-3p,TC,NLR and PLR levels were all relevant factors affecting patients with left ventricular hypertrophy(P<0.05).ROC curve analysis showed that the age,miR-499-5p,miR-423-5p,miR-210-3p,TC,NLR and PLR had high sensitivity and specificity in predicting whether left ventricular hypertrophy was complicated,and the combined prediction of various indicators had higher value(P<0.05).Conclusion:Age,micronucleic acids(miR-499-5p,miR-423-5p,miR-210-3p),TC,NLR and PLR levels will lead to an increased risk of left ventricular hypertrophy in patients with coronary heart disease.Combined detection of micronucleic acids,TC,NLR,and PLR has high value in predicting left ventricular hypertrophy in patients with coronary heart disease.
作者
陈少鹏
李秀芩
王素星
邵伟华
白雪冬
姚丽霞
CHEN Shao-peng;LI Xiu-qin;WANG Su-xing;SHAO Wei-hua;BAI Xue-dong;YAO Li-xia(Department of Prevention and Health,Hebei General Hospital,Shijiazhuang 050051,Hebei,China;Department of Elderly Cardiovascular Disease Internal MedicineⅡ,Hebei General Hospital,Shijiazhuang 050051,Hebei,China)
出处
《川北医学院学报》
CAS
2023年第11期1504-1507,共4页
Journal of North Sichuan Medical College
基金
河北省卫生计生委医学科学研究重点课题(20180147)。
作者简介
陈少鹏(1984-),男,硕士,主治医师。E-mail:xiuqinli2019@163.com;通讯作者:姚丽霞,博士。E-mail:yaolx2022@163.com。
