摘要
目的:研究经胆道注射吲哚菁绿(ICG)荧光显影指导下腹腔镜胆囊切除术(LC)治疗急性胆囊炎患者的效果。方法:回顾性分析2021年2月—2022年9月蚌埠医学院第一附属医院收治的60例急性胆囊炎患者资料。根据不同手术方法将其分为对照组及研究组,各30例。对照组给予常规LC,研究组给予经胆道注射ICG荧光显影指导下LC。比较两组围手术期指标,术前、术后3 d炎症因子、肝功能指标及并发症。结果:研究组的胆管识别时间、手术时间均短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05)。术后3 d,两组白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平均降低,研究组IL-6、CRP、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。术后3 d,两组天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、碱性磷酸酶(ALP)水平均降低,研究组AST、ALT、ALP水平均低于对照组,差异有统计学意义(P<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:经胆道注射ICG荧光显影指导下LC可改善手术指标,缓解机体炎症,促进肝功能恢复,但二者术后并发症未存在差异,今后需扩大研究样本进一步证实。
Objective:To investigate the efficacy of laparoscopic cholecystectomy(LC)guided by transbiliary injection of Indocyanine Green(ICG)fluorescence imaging in the treatment of patients with acute cholecystitis.Method:The data of sixty patients with acute cholecystitis admitted to the First Affiliated Hospital of Bengbu Medical College from February 2021 to September 2022 were retrospectively analyzed.According to different surgical methods,the patients were divided into control group and study group,30 cases in each group.The control group was given conventional LC,and the study group was given LC guided by transbiliary injection of ICG fluorescence imaging.Perioperative indexes,inflammatory factors,liver function indexes before and 3 d after operation and complications were compared between the two groups.Result:The bile duct identification time and operation time of the study group were shorter than those of the control group,and the intraoperative blood loss volume was less than that of the control group,the differences were statistically significant(P<0.05).At 3 d after operation,the levels of interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in both groups were decreased,and the levels of IL-6,CRP and TNF-αin the study group were lower than those in the control group,the differences were statistically significant(P<0.05).At 3 d after operation,the levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT)and alkaline phosphatase(ALP)in both groups were decreased,and the levels of AST,ALT and ALP in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion:LC guided by transbiliary injection of ICG fluorescence imaging can improve surgical indexes,relieve body inflammation and promote liver function recovery,but there is no difference in postoperative complications between the two,and it is necessary to expand the research samples for further confirmation in the future.
作者
王超
周凯
WANG Chao;ZHOU Kai(The First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,China)
出处
《中外医学研究》
2023年第31期50-53,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
腹腔镜胆囊切除术
吲哚菁绿
炎症因子
肝功能
Laparoscopic cholecystectomy
Indocyanine
Green
Inflammatory factors
Liver function
作者简介
通信作者:周凯。
