摘要
目的回顾性分析不稳定型心绞痛治疗中不同剂量阿托伐他汀钙联合氯吡格雷的临床效果及对血脂水平、心功能指标、炎性因子水平的影响。方法选取2021年3月—2022年10月北京市红十字会急诊抢救中心收治的不稳定型心绞痛患者86例为研究对象,依据患者不同的治疗方法分为对照组43例和研究组43例,对照组给予阿托伐他汀钙10 mg/d联合氯吡格雷治疗,研究组给予阿托伐他汀钙20 mg/d联合氯吡格雷治疗,对比两组临床效果及治疗前后的血脂水平、心功能指标和炎性因子水平。结果研究组临床总有效率为97.67%,高于对照组的83.72%,差异有统计学意义(χ^(2)=4.962,P=0.026)。治疗后,研究组总胆固醇、低密度脂蛋白胆固醇水平低于对照组,高密度脂蛋白胆固醇水平高于对照组,差异有统计学意义(P<0.05)。治疗后,两组三酰甘油水平比较,差异无统计学意义(P>0.05)。治疗后,研究组患者的心功能指标优于对照组,炎性指标水平低于对照组,差异有统计学意义(P<0.05)。结论与阿托伐他汀10 mg/d联合氯吡格雷治疗不稳定型心绞痛患者相比,服用阿托伐他汀20 mg/d患者的临床治疗效果更好,用药后调脂作用、改善心功能,抗炎效果更加显著,血管的保护作用更强。
Objective To retrospectively analyze the clinical efficacy of different doses of atorvastatin calcium com-bined with clopidogrel in the treatment of unstable angina pectoris and the effects of lipid levels,cardiac function indi-ces,and inflammatory factor levels.Methods Eighty-six patients with unstable angina pectoris admitted to Beijing Red Cross Emergency Rescue Center from March 2021 to October 2022 were selected as the study objects and di-vided into 43 cases in the control group and 43 cases in the study group according to different treatments of the pa-tients.The control group was treated with atorvastatin calcium 10 mg/d combined with clopidogrel,and the study group was treated with atorvastatin calcium 20 mg/d combined with clopidogrel.The clinical effects,and lipid levels,cardiac function indexes and inflammatory factor levels before and after treatment were compared between the groups.Results The total clinical effectiveness rate of patients in the study group was 97.67%,which was higher than 83.72%in the control group,and the difference was statistically significant(χ^(2)=4.962,P=0.026).After treatment,the total cho-lesterol and low density lipoprotein cholesterol levels of the patients in the study group were significantly lower than those in the control group,the high density lipoprotein cholesterol levels were higher than those of the control group,and the difference was statistically significant(P<0.05).The difference in triglyceride levels between the two groups were compared after treatment,and the difference was not statistically significant(P>0.05).After treatment,the car-diac function indexes of the patients in the study group were significantly better than those in the control group,and the inflammatory index level were significantly lower than those in the control group,and the difference was statisti-cally significant(P<0.05).Conclusion Compared with atorvastatin 10 mg/d combined with clopidogrel in the treat-ment of patients with unstable angina pectoris,the clinical therapeutic effect of patients taking atorvastatin 20 mg/d is better,the lipid-regulating effect of the drug,improve cardiac function,anti-inflammatory effect is more significant,and the vascular protective effect is stronger.
作者
吕伟娟
章晓峰
侯兰
LYU Weijuan;ZHANG Xiaofeng;HOU Lan(Department of Internal Medicine,Beijing Red Cross Emergency Rescue Center,Beijing,100020 China)
出处
《系统医学》
2023年第17期132-135,共4页
Systems Medicine
作者简介
吕伟娟(1977-),女,专科,主治医师,研究方向为老年内科疾病诊治工作。
