摘要
肠道机械屏障是人体抵御肠道细菌的第一道防线,其损伤会导致多种疾病的发生。乳杆菌作为益生菌具有广阔的临床应用前景,能够刺激肠上皮细胞增殖与分化、减少肠上皮细胞死亡、增强肠上皮细胞间连接、促进粘蛋白分泌从而改善和维持肠道机械屏障。本文对乳杆菌在保护肠机械屏障方面的作用与机制进行综述,旨在加深对乳杆菌的了解,探讨其在未来的临床实践中对肠道疾病的预防和治疗,启发在临床应用乳杆菌及其产品的新微生物策略。
The intestinal mechanical barrier is the first line of defense against intestinal bacteria,and its damage can lead to a variety of diseases.Lactobacillus,as a probiotic with clinical application prospect,can stimulate the proliferation and differentiation of intestinal epithelial cells,reduce the death of intestinal epithelial cells,enhance the connectivity between intestinal epithelial cells,and promote mucin secretion and improve and maintain the mechanical barrier of intestinal tract.This article reviews the role and mechanism of Lactobacillus in protecting the intestinal mechanical barrier,aiming to deepen the understanding of Lactobacillus,explore its prevention and treatment of intestinal diseases in future clinical practice,and inspire new microbial strategies for the clinical application of Lactobacillus and its products.
作者
黄龙昌
王鹏
王新颖
HUANG Long-chang;WANG Peng;WANG Xin-ying(Institute of General Surgery,Nanjing Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210002,Jiangsu,China)
出处
《肠外与肠内营养》
CAS
CSCD
北大核心
2023年第5期315-320,共6页
Parenteral & Enteral Nutrition
基金
国自然基金面上项目(82170575)。
关键词
肠道
乳杆菌
机械屏障
Gut
Lactobacillus
Mechanical barrier
作者简介
黄龙昌,住院医师,医学博士,主要从事结直肠癌及肠外与肠内营养的基础和临床研究。E-mail:yongyeyonghen@163.com;通讯作者:王新颖,E-mail:wangxinying@nju.edu.cn。
