摘要
目的 探讨通过检测血清甲胎蛋白(AFP)与前白蛋白(PA)来评估肝动脉化疗栓塞术(TACE)治疗原发性肝癌疗效及预后的临床价值。方法 选取2018年2月-2022年4月如皋市中医院50例行TACE治疗的原发性肝癌患者。治疗前及治疗后1个月,测定患者血清AFP与PA,分析两项指标与TACE后碘油沉积的相关性,比较观察TACE不同疗效及随访1年不同预后患者的指标差异。结果 Pearson相关性分析显示血清AFP水平与碘油沉积分级呈负相关(P<0.05)。TACE治疗有效患者术前及术后1个月血清AFP低于治疗无效患者,血清PA高于治疗无效患者,差异有统计学意义(P<0.05)。随访1年生存患者术前及术后1个月、3个月、6个月血清AFP低于死亡患者,血清PA高于死亡患者,差异有统计学意义(P<0.05)。受试者工作特征(ROC)曲线结果显示,血清AFP与PA的曲线下面积(AUC)均>0.7,可预测TACE疗效及患者预后且联合预测价值更高。结论 监测血清AFP与PA可以为临床评估TACE治疗原发性肝癌的疗效及预后提供有价值的参考,联合应用可进一步提高预测价值。
Objective To explore clinical value of detecting serum alpha fetoprotein(AFP)and prealbumin(PA),and evaluate effect and prognosis of hepatic artery chemoembolization(TACE)in treatment of primary liver cancer.Methods The paper chose 50 patients with primary liver cancer treated with TACE in Rugao City Hospital of Traditional Chinese Medicine from February 2018 to April 2022,serum AFP and PA were detected before and one month after treatment,correlation between two indicators and iodine oil deposition after TACE was analyzed.Difference in indicators between patients with different TACE effect and 1-year follow-up was compared and observed.Results Pearson correlation analysis showed negative correlation between serum AFP levels and iodine oil deposition grading(P<0.05).Serum AFP of patients with TACE treatment was lower than patients with ineffective treatment before and 1 month after surgery,serum PA was higher than patients with ineffective treatment,with statistically significant difference(P<0.05).Patients survived for 1 year had lower serum AFP levels and higher serum PA levels than those died before and 1,3 and 6 months after surgery,with statistically significant difference(P<0.05).Results of receiver operating characteristic(ROC)curve showed,area under curve(AUC)of serum AFP and PA was both larger than 0.7,which could predict effect of TACE and patient prognosis and combined predictive value was higher.Conclusion Monitoring serum AFP and PA can provide valuable reference for clinical effect and prognosis evaluation of TACE treatment for primary liver cancer,combined application can further improve the predictive value.
作者
陈光耀
刘海华
杨小锋
康东
CHEN Guangyao;LIU Haihua;YANG Xiaofeng;KANG Dong(Department of Vascular Intervention,Rugao City Hospital of Traditional Chinese Medicine,Rugao,Jiangsu 226500;General Surgery Department,Rugao City Hospital of Traditional Chinese Medicine,Rugao,Jiangsu 226500)
出处
《智慧健康》
2023年第20期199-202,207,共5页
Smart Healthcare
关键词
原发性肝癌
肝动脉化疗栓塞术
甲胎蛋白
前白蛋白
疗效
预后
Primary liver cancer
Hepatic artery chemoembolization
Alpha fetoprotein
Pre albumin
Curative effect
Prognosis
作者简介
陈光耀(1978-),男,江苏如皋,汉族,本科,副主任医师,研究方向:介入诊疗以及影像诊断;通信作者:刘海华(1990-),男,江苏如皋,汉族,本科,主治医师,研究方向:介入放射治疗与影像诊断。
