摘要
肺癌在全球范围内的发病率和病死率均较高,其中以非小细胞肺癌(NSCLC)为主。虽然近年关于NSCLC的治疗已取得一定进展,但目前其发病机制尚未明确,导致患者预后较差。长链非编码RNA(lncRNA)在NSCLC的发生发展中起重要调节作用,其主要机制可能为lncRNA通过调控磷脂酰肌醇-3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白、Wnt/β联蛋白、Janus激酶/信号转导及转录活化因子、核因子κB等信号通路的激活参与细胞增殖、凋亡及迁移等过程。因此,未来深入研究lncRNA与NSCLC相关信号通路在NSCLC中的作用,对于寻找NSCLC新的诊断及治疗策略具有重要意义。
Lung cancer has a high morbidity and mortality worldwide,and non-small cell lung cancer(NSCLC)is the main type.Although the treatment of NSCLC has made a certain amount of progress in recent years,the prognosis of the patients remains poor due to the unclear pathogenesis.Long non-coding RNA(lncRNA)plays an important regulatory role in the occurrence and development of NSCLC.The main mechanism may be that lncRNA can participate in the process of cell proliferation,apoptosis and migration by regulating the activation of phosphatidylinositol-3-kinase/protein kinase B/mammalian rapamycin target protein,Wnt/β-catenin,Janus kinase/signal transduction and transcription activator and nuclear factor-κB signaling pathways.Therefore,in-depth exploration of the role of lncRNA and NSCLC-related signaling pathways in NSCLC is of great significance for finding new diagnostic and therapeutic strategies for NSCLC.
作者
胡波涛
赵丽
黄沈阳
刘欢
黄健
HU Botao;ZHAO Li;HUANG Shenyang;LIU Huan;HUANG Jian(Guangdong Medical University,Zhanjiang 524000,China;Department of Thoracic Surgery,Maoming People′s Hospital,Maoming 525000,China)
出处
《医学综述》
CAS
2023年第21期4518-4522,4528,共6页
Medical Recapitulate
基金
茂名市人民医院高水平医院建设科研专项(zx2020018)。
作者简介
通信作者:黄健,Email:huangge2141@163.com。
