摘要
目的 探讨胃泌素-17(FsG-17)检测对反流性咽喉炎患者临床诊断的应用价值。方法 选取广州市中西医结合医院(本院)2020年2月至2022年1月接受门诊治疗的60例反流性咽喉炎患者作为观察组,并选取在本院同期进行体检的60名健康者作为对照组。比较两组胃蛋白酶原(FsPG)、FsG-17水平。结果 观察组FsG-17水平[1.81(0.80,8.50)pmol/L]明显高于对照组[1.12(0.45,2.49)pmol/L],差异有统计学意义(P<0.05);观察组FsPG Ⅰ[(147.20±68.69)μg/L]、FsPG Ⅱ[7.39(4.90,13.79)μg/L]、FsPGR(13.49±5.20)水平与对照组[(127.58±57.02)μg/L、7.90(5.40,20.01)μg/L、(16.49±10.30)]比较,差异无统计学意义(P>0.05);观察组Ⅰ级患者(评分RSI<13分和/或RFS<7分)FsG-17水平[(66.58±6.26)pmol/L]与Ⅱ级患者(RSI>13分和/或RFS>7分)FsG-17水平[(67.25±7.01)pmol/L]比较,差异无统计学意义(P>0.05);FsG-17诊断反流性咽喉炎的ROC曲线结果显示,最佳临界值为5.23 pmol/L、敏感度为31.08%、特异度为97.24%。结论 FsPG在反流性咽喉炎的诊断中无显著临床意义。FsG-17含量的高低与反流性咽喉炎的严重程度无相关,同时该指标敏感度虽低,但特异度高,可以结合其他临床检测提高其敏感度,对反流性咽喉炎进行诊断和筛查。
Objective To explore the clinical diagnostic application value of fasting serumgastrin-17(FsG-17)in patients with laryngopharygeal reflux.Methods A total of 60 patients with laryngopharygeal reflux who received outpatient treatment at Guangzhou Hospital of Integrated Traditional and Western Medicine from February 2020 to January 2022 were selected as the observation group,and 60 healthy individuals who underwent physical examinations at our hospital during the same period were selected as the control group.The levels of pepsinogen(FsPG)and FsG-17 were compared between the two groups.Results The level of FsG-17 in the observation group(1.81[0.80,8.50]pmol/L)was significantly higher than that in the control group(1.12[0.45,2.49]pmol/L),with a statistically significant difference(P<0.05).There was no statistically significant difference in the levels of FsPGⅠ([147.20±68.69]μg/L),FsPGⅡ(7.39[4.90,13.79]μg/L),FsPGR(13.49±5.20)in the observation group and([127.58±57.02]μg/L,7.90[5.40,20.01]μg/L,[16.49±10.30])in the control group(P>0.05).There was no statistically significant difference in FsG-17 levels between gradeⅠ(RSI<13 and/or RFS<7)patients in the observation group([66.58±6.26]pmol/L)and gradeⅡ(RSI>13 and/or RFS>7)patients([67.25±7.01]pmol/L)(P>0.05).The receiver operating characteristic curve of FsG-17 for the diagnosis of laryngopharygeal reflux showed that the optimal critical value was 5.23 pmol/L,the sensitivity was 31.08%,and the specificity was 97.24%.Conclusion FsPG has no significant clinical significance in the diagnosis of laryngopharygeal reflux;the high content of FsG-17 is not significantly correlated with the severity of laryngopharygeal reflux.Although the sensitivity of this index is low,its specificity is high.It can be combined with other clinical tests to improve its sensitivity for the diagnosis and screening of laryngopharygeal reflux.
作者
尹少林
曾伟
刘春玲
YIN Shaoin;ZENG Wei;LIU Chuning(Health Management Center,Guangzhou Hospital of Integrated Traditional and Western Medicine,Guangdong,Guangzhou 510800,China;Otolaryngology Department,Guangzhou Hospital of Integrated Traditional and Western Medicine,Guangdong,Guangzhou 510800,China;Health Examination Center,Guangzhou Hospital of Integrated Traditional and Western Medicine,Guangdong,Guangzhou 510800,China)
出处
《中国医药科学》
2023年第21期187-190,共4页
China Medicine And Pharmacy
基金
广东省广州市花都区科技计划项目(21-HDWS-087)。
关键词
反流性咽喉炎
胃泌素-17
胃蛋白酶原
应用价值
Laryngopharygeal reflux
Fasting serumgastrin-17
Pepsinogen
Application value
