摘要
目的研究超声造影精准穿刺在经直肠前列腺穿刺活检中的应用效果,旨在提高穿刺阳性率、减轻患者痛苦,为临床诊治提供依据。方法选择2019年7月-2022年12月浙江省荣军医院收治的150例前列腺特异性抗原(PSA)升高、前列腺结节患者,按照随机数表法分为对照组(75例)与观察组(75例),2组均行经直肠前列腺穿刺活检,对照组于常规超声引导下穿刺,观察组于超声造影下精准穿刺。每组按PSA值分4个区间,第一组:4 ng/mL<PSA≤10 ng/mL;第二组:10 ng/mL<PSA≤20 ng/mL;第三组:20 ng/mL<PSA≤40 ng/mL;第四组:PSA>40 ng/mL。比较2组患者相关指标、不良反应发生情况,以及4个区间穿刺活检病理的恶性检出率。结果观察组穿刺针数与对照组相近(P>0.05);阳性针数[(1.84±0.52)针]、Gleason评分[(7.25±1.22)分]高于对照组[(1.56±0.41)针、(6.32±1.06)分,均P<0.05]。观察组不良反应发生率(9.33%,7/75)低于对照组(46.67%,35/75,P<0.05)。观察组的恶性检出率(52.00%,39/75)高于对照组(34.67%,26/75,P<0.05)。2组不同PSA区间穿刺活检病理的恶性检出率比较差异有统计学意义(P<0.05)。结论超声造影精准穿刺在经直肠前列腺穿刺活检中应用效果较好,可提高穿刺阳性率与前列腺癌检出率,且能减少不良反应,值得推广。
Objective To study the application effect of contrast-enhanced ultrasound precise puncture in transrectal prostate biopsy,aiming to improve the puncture positive rate,reduce patient pain,and provide a basis for clinical diagnosis and treatment.Methods A total of 150 patients with elevated prostate specific antigen(PSA)and prostate nodules admitted to the Rongjun Hospital of Zhejiang Province from July 2019 to December 2022 were selected and divided into control group(75 cases)and observation group(75 cases)according to the random number table method.Both groups underwent transrectal prostate biopsy,the control group undergoing routine ultrasound guided puncture,while the observation group undergoing precise ultrasound contrast-enhanced puncture.Each group was divided into four intervals based on PSA values,the first group:4 ng/mL<PSA≤10 ng/mL;the second group:10 ng/mL<PSA≤20 ng/mL;the third group:20 ng/mL<PSA≤40 ng/mL;the fourth group:PSA>40 ng/mL.The related indicators(number of puncture needles,number of positive needles,Gleason score),incidence of adverse reactions(slight hematuria,fever,rectal bleeding,urinary retention,dysuria),and malignant detection rate of biopsy pathology in four regions were compared between the two groups.Results The number of puncture needles in the observation group was similar to that in the control group(P>0.05).The number of positive needles[(1.84±0.52)needles]and Gleason score[(7.25±1.22)points]were higher than those in the control group[(1.56±0.41)needles,(6.32±1.06)points,both P<0.05].The incidence of adverse reactions in the observation group(9.33%,7/75)was lower than that in the control group(46.67%,35/75,P<0.05).The malignant detection rate in the observation group(52.00%,39/75)was higher than that in the control group(34.67%,26/75,P<0.05).The difference in malignant detection rate of puncture biopsy pathology between different zones in the 2 groups was statistically significant(P<0.05).Conclusion The application of contrast-enhanced ultrasound precise puncture in transrectal prostate biopsy has a good effect,can improve the positive rate of puncture and the detection rate of prostate cancer,and can reduce adverse reactions,which is worthy of application.
作者
何佳
刘宁
于田强
时开元
段跃
HE Jia;LIU Ning;YU Tianqiang;SHI Kaiyuan;DUAN Yue(Urology Department,Rongjun Hospital of Zhejiang Province,Jiaxing,Zhejiang 314000,China;不详)
出处
《中华全科医学》
2023年第11期1920-1923,共4页
Chinese Journal of General Practice
基金
浙江省基础公益研究计划项目(LY20H270003)
嘉兴市科技计划项目(2020AD30003)。
关键词
超声造影
精准穿刺
经直肠前列腺穿刺活检
前列腺癌
诊断
Contrast-enhanced ultrasound
Accurate puncture
Transrectal prostate biopsy
Prostate cancer
Diagnosis
作者简介
通信作者:何佳,E-mail:zjrjyyhj@163.com。
