摘要
认知功能障碍作为一种常见的神经系统疾病,以认知减退、记忆力和注意力障碍为主要临床表现,严重影响患者的生存质量,是当前医学研究的热点和难点。认知功能障碍的病因及发病机制复杂多样,研究表明慢性持续性神经炎症在其发生发展中发挥关键作用。小胶质细胞、核苷酸结合寡聚化结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)炎症小体与神经炎症、认知功能障碍密切相关,调控小胶质细胞、NLRP3炎症小体可减少炎症因子、减少β淀粉样蛋白沉积、调控自噬、维持突触稳态,达到减轻神经炎症,进而防治认知功能障碍的作用。因此,阐明小胶质细胞、NLRP3炎症小体及二者共同在认知功能障碍中的作用机制,可为认知功能障碍相关机制的深入研究及临床防治、药物研发提供参考和依据。
As a common neurological disease,cognitive impairment is characterized by cognitive de-cline,memory and attention impairment,which seriously affects the patients'quality of life.The etiology and pathogenesis of cognitive impairment are complex and diverse.Studies have shown that chronic persistent neuroinflammation plays a key role in its development.Microglia and nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome are closely related to neuroinflammation and cognitive impair-ment.Regulation of microglia and NLRP3 inflammasome can reduce inflammatory factors,reduce amyloidβ-protein(Aβ)deposition,regulate autophagy,maintain synaptic homeostasis,thus reducing neuroinflam-mation and further preventing and treating cognitive impairment.Therefore,exploring the mechanism of micro-glia and NLRP3 inflammasome as well as their interaction in cognitive impairment can provide some reference and basis for the in-depth study of the mechanism and clinical prevention and treatment of cognitive impair-ment,and the subsequent development of more efficient drugs.
作者
王彩红
刘荣鑫
汤峰
魏晓涛
徐紫清
侯怀晶
张杰
赵永强
薛建军
WANG Caihong;LIU Rongxin;TANG Feng;WEI Xiaotao;XU Ziqing;HOU Huaijing;ZHANG Jie;ZHAO Yongqiang;XUE Jianjun(First Clinical Medical School,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Anesthesiology,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,China;Gansu Province Integrative Medicine Anesthesia Clinical Research Center,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Institute of Traditional Chinese and Western Medicine Anesthesia and Evidence-based Medicine Institute,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,China;Department of Urology,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,China)
出处
《协和医学杂志》
CSCD
2023年第6期1282-1288,共7页
Medical Journal of Peking Union Medical College Hospital
基金
甘肃省科技计划项目-临床医学研究中心建设(20JR10RA435)
甘肃省科技计划项目-重点研发计划(22YF7FA101)。
作者简介
通信作者:薛建军,E⁃mail:xjjfei419@163.com;通信作者:赵永强,E⁃mail:1114221808@qq.com。
