摘要
目的 分析血清同型半胱氨酸(Hcy)、25羟维生素D [25(OH)D]与2型糖尿病周围神经病变(DPN)的相关性。方法 研究对象为2型糖尿病(T2DM)患者,随机选取120例,在入院时经神经电生理检查,并结合体格检查、一般情况分析等结果 ,将其分为2组:48例对象为DPN组,72例对象未合并DPN(NDPN组);另选取同期健康体检者50例(正常对照组),两组对象的基本资料完善,并采集其血清样本,对血脂、Hcy、血糖、25(OH)D等相关指标予以检测及对比,分析与DPN发生的相关性。结果 DPN组、NDPN组患者血清Hcy高于正常对照组,25(OH)D水平低于正常对照组,且DPN组血清Hcy高于NDPN组,25(OH)D水平低于NDPN组(P<0.01);DPN组正中神经MCV、腓总神经MCV及正中神经SCV、尺神经SCV、腓肠神经SCV均低于NDPN组(P<0.01);采用Spearman相关性分析,血清Hcy与糖尿病病程、FBG、2h-PBG、HbA1c呈正相关,而25(OH)D水平与上述指标呈负相关;血清Hcy与正中神经、腓总神经的MCV及与正中神经、尺神经、腓肠神经的SCV为负相关,而25(OH)D水平与上述指标呈正相关(PP<0.05);Logistic回归分析:DPN的保护因素的为25(OH)D,糖尿病病程、Hcy为危险因素(P<0.05)。结论 当存在血清25(OH)D缺乏、Hcy升高以及糖尿病病程长,极易增加T2DM患者合并DPN风险,此时补充维生素D,降低Hcy水平,对延缓DPN疾病发生及进展有重要意义。
Objective To analyze the association between serum homocysteine(Hcy)and 25-hydroxyvitamin D[25(OH)D]and type 2 diabetic peripheral neuropathy(DPN).Methods The subjects were patients with type 2 diabetes mellitus(T2DM).120 cases were randomly selected and divided into two groups after electrophysiological examination,physical examination,general situation analysis and other results:48 cases were in the DPN group,and 72 cases were not combined with DPN(NDPN group);Another 50 healthy individuals(normal control group)were selected for the same period of physical examination.The basic information of the two groups was complete,and their serum samples were collected to detect and compare related indicators such as blood lipids,Hcy,blood glucose,25(OH)D,and analyze the correlation with the occurrence of DPN.Results The serum Hcy of patients in the PN and NDPN groups was higher than that of the normal control group,and the level of 25(OH)D was lower than that of the normal control group.Additionally,the serum Hcy of patients in the DPN group was higher than that in the NDPN group,and the level of 25(OH)D was lower than that in the NDPN group(P<0.01);The median nerve MCV,common peroneal nerve MCV,median nerve SCV,ulnar nerve SCV,and sural nerve SCV in the DPN group were lower than those in the NDPN group(P<0.01);Spearman correlation analysis showed that serum Hcy was positively correlated with the course of diabetes,FBG,2h PBG,HbA1c,and 25(OH)D was negatively correlated with the above indicators;Serum Hcy was negatively correlated with MCV of the median and common peroneal nerves,as well as SCV of the median,ulnar,and sural nerves,while 25(OH)D levels were positively correlated with the above indicators(P<0.05);Logistic regression analysis:the protective factor of DPN was 25(OH)D,and the course of diabetes and Hcy were risk factors(P<0.05).Conclusion When there is a lack of serum 25(OH)D,an increase in Hcy and a long course of diabetes,it is very easy to increase the risk of T2DM patients with DPN.At this time,vitamin D supplementation and a decrease in Hcy level are of great significance to delay the occurrence and progress of DPN disease.
作者
李旭
闫晓玲
杜晓洋
田德增
LI Xu;YAN Xiao-ling;DU Xiao-yang;TIAN De-zeng(Department of Endocrinology,Anyang District Hospital,Puyang 455000,Henan Province,China)
出处
《罕少疾病杂志》
2023年第11期95-97,共3页
Journal of Rare and Uncommon Diseases
作者简介
第一作者:李旭,女,主治医师,主要研究方向:糖尿病、甲状腺等内分泌相关疾病诊治。E-mail:mz5566772022@163.com;通讯作者:田德增,男,主任医师,主要研究方向:糖尿病、甲状腺等内分泌相关疾病诊治。E-mail:tiandezeng@126.com。
