摘要
非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)和心房颤动(atrial fibrillation,AF)是常见的慢性非传染性疾病,发病率呈上升趋势。多项研究证实,NAFLD是AF发病的独立危险因素。然而,由于混杂因素的普遍存在,NAFLD在AF发展中的独立致病作用仍需进一步研究。NAFLD引起AF的机制包括心外膜脂肪组织(epicardial adipose tissue,EAT)增加、心肌重构、脂联素水平降低等,以及促进炎症、氧化应激和纤维化的常见疾病途径的激活。此外,多种药物对NAFLD和AF同时具有治疗作用,NAFLD和AF共同的发病机制可能成为未来潜在的治疗靶点。
Non-alcoholic fatty liver disease(NAFLD)and atrial fibrillation(AF)are common chronic noncommunicable diseases,and their incidence is on the rise.Many studies have confirmed that NAFLD is an independent risk factor for AF.However,due to the presence of confounding factors,the independent pathogenicity of NAFLD in the development of AF still needs further study.Mechanisms by which NAFLD induces AF include increased epicardial adipose tissue(EAT),myocardial remodeling,decreased adiponectin levels,and activation of common disease pathways that promote inflammation,oxidative stress,and fibrosis.In addition,multiple drugs have therapeutic effects on both NAFLD and AF,and the common pathogenesis of NAFLD and AF may become potential therapeutic targets in the future.
作者
邵宝兴
陈良华
SHAO Baoxing;CHEN Lianghua(Department of Cardiology,Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)
出处
《山东第一医科大学（山东省医学科学院）学报》
CAS
2023年第10期790-796,共7页
Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences
关键词
非酒精性脂肪性肝病
心房颤动
心外膜脂肪
脂联素
nonalcoholic fatty liver disease
atrial fibrillation
epicardial fat tissue
adiponectin
作者简介
邵宝兴,硕士研究生,研究方向:心房颤动,E-mail:2752512621@qq.com;通信作者:陈良华,博士,主任医师,研究方向:心房颤动,E-mail:m18766043870@163.com。
