摘要
目的:观察葡萄糖酸锌颗粒联合双歧杆菌四联活菌片治疗小儿轮状病毒感染性腹泻的效果。方法:选取2021年10月至2023年1月该院收治的156例轮状病毒感染性腹泻患儿进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各78例。对照组给予双歧杆菌四联活菌片治疗,观察组在对照组基础上联合葡萄糖酸锌颗粒治疗,比较两组临床疗效,治疗前后炎性因子[高迁移率族蛋白-1(HMGB-1)、降钙素原(PCT)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)]水平和T细胞亚群指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平,肠道菌群指标(肠球菌属、乳杆菌属、酵母样真菌)水平及不良反应发生率。结果:观察组治疗总有效率为96.15%,高于对照组的78.49%,差异有统计学意义(P<0.05);治疗后,观察组HMGB-1、PCT、IL-6及hs-CRP水平均低于对照组,差异有统计学意义(P<0.05);观察组乳杆菌属水平高于对照组,肠球菌属、酵母样真菌水平均低于对照组,差异有统计学意义(P<0.05);观察组CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:葡萄糖酸锌颗粒联合双歧杆菌四联活菌片治疗轮状病毒感染性腹泻患儿,可提高临床疗效,减轻机体炎症反应,调节肠道菌群,增强免疫功能,效果优于单纯双歧杆菌四联活菌片治疗。
Objective:To observe effects of Zinc gluconate granules combined with Bifidobacterium quadruple viable tablets in treatment of children with rotavirus infectious diarrhea.Methods:A prospective study was conducted on 156 children with rotavirus infection diarrhea admitted to the hospital from October 2021 to January 2023.According to the random number table method,they were divided into control group and observation group,78 cases in each group.The control group was treated with Bifidobacterium quadruple viable tablets,while the observation group was treated with Zinc gluconate granules on the basis of that of the control group.The clinical efficacy,the levels of inflammatory factors[high mobility group protein-1(HMGB-1),procalcitonin(PCT),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)]and T cell subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))before and after the treatment,the levels of intestinal flora indicators(Enterococcus,Lactobacillus,yeast-like fungi),and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 96.15%,which was higher than 78.49%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of HMGB-1,PCT,IL-6 and hs-CRP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of Lactobacillus in the observation group were higher than those in the control group,the levels of Enterococcus and yeast-like fungi were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,the level of CD8^(+)was lower than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Zinc gluconate granules combined with Bifidobacterium quadruple viable tablets in the treatment of the children with rotavirus infectious diarrhea can improve the clinical efficacy,reduce the inflammatory reactions,regulate the intestinal flora,and enhance the immune function.Moreover,it is superior to single Bifidobacterium quadruple viable tablets treatment.
作者
李金霞
刘慧慧
LI Jinxia;LIU Huihui(Department of Pediatrics of Qi County People’s Hospital,Kaifeng 475200 Henan,China)
出处
《中国民康医学》
2023年第20期95-98,共4页
Medical Journal of Chinese People’s Health
关键词
轮状病毒感染性腹泻
双歧杆菌四联活菌片
葡萄糖酸锌
T细胞亚群
肠道菌群
炎性因子
Rotavirus infectious diarrhea
Bifidobacterium quadruple viable tablets
Zinc gluconate
T cell subset
Intestinal flora
Inflammatory factor
作者简介
李金霞(1985.03-),女,汉族,河南杞县人,本科,主治医师,研究方向为肺炎支原体肺炎、小儿轮状病毒感染诊疗。
