摘要
目的探讨炎症性肠病(IBD)患者幽门螺杆菌(Hp)感染情况及二者的相互关系。方法选取2018年1月至2022年6月在解放军联勤保障部队第九二四医院消化科初次诊断的115例IBD患者作为本研究的观察组,其中溃疡性结肠炎(UC)组患者83例、克罗恩病(CD)组患者32例,同时选取性别、年龄相匹配的同期健康体检者115名作为对照组,两组受检者进行14C呼气试验和/或胃黏膜病理免疫组织化学染色检测Hp感染情况,比较两组受检者Hp感染情况,分析IBD患者中不同病变范围、病变行为、疾病活动程度与Hp感染的可能关系。结果观察组中总体Hp感染率为31.30%,其中UC组、CD组Hp感染率分别为32.53%、28.13%,均明显低于对照组的59.13%,差异有统计学意义(P<0.05);比较UC组与CD组Hp感染率,差异无统计学意义(P>0.05);分别对UC组和CD组中不同病变范围、病变行为、疾病活动程度的Hp感染率比较,差异均无统计学意义(P>0.05)。结论IBD患者Hp总体感染率显著低于健康人群,Hp感染可能是IBD发生的一个保护性因素,与IBD疾病本身严重程度无明显关系。
Objective To explore the Helicobacter pylori(Hp)infection in patients with inflammatory bowel disease(IBD)and the relationship between the two.Methods A total of 115 patients with IBD who were initially diagnosed in the Department of Gastroenterology,the 924th Hospital of the Joint Logistics Support Force of the People’s Liberation Army from January 2018 to June 2022 were included in the observation group(n=115)in this study,including 83 patients with ulcerative colitis(UC)and 32 patients with Crohn’s disease(CD),and 115 health examinees of the same period with matched gender and age were included in the control group.The two groups of subjects were tested for Hp infection by 14C urea breath test and(or)pathological immunohistochemical staining of gastric mucosa,the Hp infection of the two groups of subjects was compared,and the possible relationship between different lesion areas,lesion behaviors,and disease activity and Hp infection in IBD patients were analyzed.Results The overall Hp infection rate in the observation group was 31.30%,with the UC group and CD group of 32.53% and 28.13%,respectively,significantly lower than 59.13% in the control group,with statistically significant difference(P<0.05).There was no statistically significant difference between the UC group and the CD group in terms of Hp infection rate(P>0.05).The Hp infection rates of patients with different lesion areas,lesion behaviors,and disease activities in the UC and CD groups were compared,without statistically significant differences(P>0.05).Conclusion The overall infection rate of Hp in patients with IBD is significantly lower than that of healthy individuals,and Hp infection may be a protective factor for the occurrence of IBD,and is not significantly related to the severity of the IBD disease itself.
作者
曹立军
熊红
黄健能
贺纳斯
李明
黄应文
罗燕英
贺学强
CAO Lijun;XIONG Hong;HUANG Jianneng;HE Nasi;LI Ming;HUANG Yingwen;LUO Yanying;HE Xueqiang(Department of Gastroenterology,the 924th Hospital of the Joint Logistics Support Force of the People’s Liberation Army,Guangxi,Guilin 541002,China)
出处
《中国医药科学》
2023年第19期169-172,共4页
China Medicine And Pharmacy
基金
广西壮族自治区卫生健康委员会计划课题项目(Z20210383)
广西壮族自治区桂林市科学研究与技术开发计划项目(2020011209-3)。
关键词
幽门螺杆菌
炎症性肠病
溃疡性结肠炎
克罗恩病
感染
相关性分析
Helicobacter pylori
Inflammatory bowel disease
Ulcerative colitis
Crohn’s disease
Infection
Correlation analysis
