摘要
目的探讨血清碱性磷酸酶(ALP)、高敏C反应蛋白(hs-CRP)对冠心病(CHD)经皮冠状动脉介入治疗(PCI)术后不良心血管事件(MACE)发生的预测价值。方法回顾性选取行PCI的CHD患者113例,依据是否发生MACE分为MACE组(n=41)和非MACE组(n=72)。比较两组临床资料和血清ALP、白蛋白(ALB)、hs-CRP水平。多因素Logistic回归分析CHD患者行PCI术后发生MACE的危险因素,ROC曲线分析ALP、hs-CRP对CHD患者行PCI后发生MACE的预测价值。结果MACE组ALP和hs-CRP高于非MACE组,ALB低于非MACE组(P<0.05)。MACE组年龄≥70岁、心肌梗死患者、BNP≥500 ng/L、左主干病变及支架数≥2个的占比均高于非MACE组(P<0.05);其他指标两组间比较差异无显著性(P>0.05)。多因素Logistic回归分析显示,年龄、BNP、ALP、hs-CRP、冠心病类型、左主干病变及支架数≥2个均为CHD患者PCI术后发生MACE的危险因素(P<0.05)。ROC曲线分析发现,血清ALP、hs-CRP联合检测对冠心病患者PCI术后MACE发生的预测价值最高(P<0.05)。结论血清ALP及hs-CRP联合检测可作为CHD患者PCI术后是否发生MACE的预测指标。
Aim To explore the predictive value of serum alkaline phosphatase(ALP)and high-sensitivity C-reactive protein(hs-CRP)on occurrence of major adverse cardiovascular events(MACE)in coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods 113 patients with CHD undergoing PCI were retrospectively selected.According to whether or not MACE occurred,the patients were classified into MACE group(n=41)and non-MACE group(n=72).Clinical data and levels of serum ALP,albumin(ALB)and hs-CRP were compared between both groups.Multivariate Logistic regression analysis was used to analyze the risk factors for MACE occurrence in patients with CHD after PCI.ROC curve was applied to analyze the predictive value of ALP,ALB and hs-CRP on the occurrence of MACE in patients with CHD after PCI.Results The ALP and hs CRP levels in the MACE group were higher than those in the non-MACE group,while the ALB levels were lower than those in the non-MACE group(P<0.05).The proportion of patients with age≥70 years old,myocardial infarction,BNP≥500 ng/L,left main artery disease,and stents≥2 in the MACE group was higher than that in the non-MACE group(P<0.05);There was no significant difference in other indicators between the two groups(P>0.05).Multivariate Logistic regression analysis showed that age,BNP,ALP,hs CRP,type of coronary heart disease,left main artery disease,and stents≥2 were all risk factors for MACE in CHD patients after PCI(P<0.05).ROC curve analysis showed that the combined detection of serum ALP and hs CRP had the highest predictive value for MACE occurrence in patients with coronary heart disease after PCI(P<0.05).Conclusion The combined detection of serum ALP and hs-CRP can be used as a predictor for postoperative MACE in patients with CHD after PCI.
作者
潘贤明
邱斐斐
刘宁静
PAN Xianming;QIU Feifei;LIU Ningjing(Department of Internal Medicine,Shandong Wendeng Osteopathic Hospital,Weihai 264400,Shandong,China;Department of Anesthesiology,Shandong Wendeng Osteopathic Hospital,Weihai 264400,Shandong,China)
出处
《中南医学科学杂志》
CAS
2023年第5期752-755,共4页
Medical Science Journal of Central South China
关键词
冠心病
经皮冠状动脉介入治疗
血清碱性磷酸酶
高敏C反应蛋白
不良心血管事件
coronary heart disease
percutaneous coronary intervention
alkaline phosphatase
high-sensitivity C-reactive protein
major adverse cardiovascular events
作者简介
潘贤明,主治医师,研究方向为心血管疾病的诊治,E-mail为panxianming2011@163.com。;通信作者:刘宁静,主治医师,研究方向为老年疾病的诊治,E-mail为lningjing2022@163.com。
