摘要
BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is the standard second-line treatment option for individuals with complications of decompensated cirrhosis,such as variceal bleeding and refractory ascites.AIM To investigate whether recompensation existed in TIPS-treated patients with decompensated cirrhosis according to Baveno VII criteria.METHODS This retrospective analysis was performed on 64 patients who received TIPS for variceal bleeding or refractory ascites.The definition of recompensation referred to Baveno VII criteria and previous study.Clinical events,laboratory tests,and radiological examinations were regularly conducted during a preset follow-up period.The recompensation ratio in this cohort was calculated.Beyond that,univariate and multivariate regression models were conducted to identify the predictors of recompensation.RESULTS Of the 64 patients with a 12-mo follow-up,20(31%)achieved recompensation.Age[odds ratio(OR):1.124;95%confidence interval(CI):1.034-1.222]and postTIPS portal pressure gradient<12 mmHg(OR:0.119;95%CI:0.024-0.584)were identified as independent predictors of recompensation in patients with decompensated cirrhosis after TIPS.CONCLUSION The present study demonstrated that nearly one-third of the TIPS-treated patients achieved recompensation within this cohort.According to our findings,recompensation is more likely to be achieved in younger patients.In addition,postoperative portal pressure gradient reduction below 12 mmHg contributes to the occurrence of recompensation.
基金
Natural Science Foundation of China,No.82200650
Key Research and Development(R and D)Projects of Shanxi Province,No.202102130501014
Shanxi Provincial Clinical Research Center for Interventional Medicine,No.202204010501004
Natural Science Foundation of Shanxi Province,No.202203021211021
Natural Science Foundation of Shanxi Province,No.202203021212046
Natural Science Foundation of Shanxi Province,No.20210302123258.
作者简介
Corresponding author:Dui-Ping Feng,MD,Chief Doctor,Department of Oncological and Vascular Intervention,First Hospital of Shanxi Medical University,No.85 Jiefang South Road,Yingze District,Taiyuan 030001,Shanxi Province,China.fengdp@sxmu.edu.cn,0000-0003-4516-3797;Long Gao,0000-0002-2803-3416;Man-Biao Li,0000-0001-5563-5052;Jin-Yu Li,0000-0003-2563-5937;Yang Liu 0009-0007-4532-3304;Chao Ren 0009-0007-4810-4086。
